Bacteria you can live without em, but it wont do you any good, according to a study of fruit flies by University of Southern California biologists.
Flies scrubbed clean of bacteria did not outlive their grubby siblings, the researchers report in the August 8 issue of Cell Metabolism.
The finding challenges the conventional wisdom that even harmless bacteria and the immune response they provoke suck up the energy of the host organism and hasten its death.
It seemed like it was dogma that if the organism has to spend energy doing something, it should shorten the animals life, said co-author and USC biologist Steven Finkel.
A research team led by John Tower, associate professor of molecular and computational biology at USC, compared normal fruit flies to ones kept in an axenic (bacteria-free) environment.
The surprise was that the flies grown under axenic conditions and the normal flies had the same life span, Tower said.
The experiment cannot be replicated in higher organisms, which need bacteria for proper digestion and other functions. But the result in flies still may be relevant to human aging research.
In both flies and humans, the number of bacteria living on the organism increases with age. The innate immune response to bacteria is similar in flies and humans, and it loses strength with age in both species.
The study suggests that all these factors may have nothing to do with aging.
I think a lot of people would just assume that if youre increasing bacterial load in an aging human, it must be bad, Finkel said.
And it might not just be bad, it just might be. Prior to this study, I would not have thought that.
The study is part of a broader effort in the Tower lab to eliminate irrelevant factors in aging and close in on its fundamental causes.
We want to determine what limits the life span of the fly, or any other animal, Tower said.'"/>
Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
7-Aug-2007