HOME >> BIOLOGY >> NEWS
Bacterial protein shows promise in treating intestinal parasites

Scientists at the University of California, San Diego and Yale University have discovered that a natural protein produced by Bacillus thuringiensis, a bacterium sprayed on crops by organic farmers to reduce insect damage, is highly effective at treating hookworm infections in laboratory animals.

Their discovery, detailed in this week's early online edition of the Proceedings of the National Academy of Sciences, could pave the way for the development of more effective treatments for hookworm and other soil-transmitted nematode infections, which are a major global health problem in developing countries. Many of the nearly two billion people worldwide infected with these intestinal parasites are children, who are at particular risk for anemia, malnutrition and delayed growth.

The UCSD-Yale team found that a protein produced by the bacterium Bacillus thuringiensis, or Bt, given orally to laboratory hamsters infected with hookworms was as effective in eliminating the parasites, curing anemia and restoring weight gain in the hamsters as mebendazole, one of the drugs currently recommended to treat infections in humans. The scientists also discovered that this protein, called Cry5B, targets both developing, or larval, stages and adult parasites, as well as impairs the excretion of eggs by female worms.

Hookworms cause anemia by attaching to the intestine and feeding on their host's blood and nutrients, causing anemia and weight loss. The researchers said in their paper that because this naturally-produced protein is safe to humans and other vertebrates and can be produced inexpensively in large quantities, it has the potential to substantially improve this global health problem.

"Our ability to control parasitic nematode infections with chemotherapy on a global scale is dependent on the availability of medicines that are safe, effective, and inexpensive to manufacture," said Michael Cappello, one of two principal authors of the
'"/>

Contact: Kim McDonald
kmcdonald@ucsd.edu
858-534-7572
University of California - San Diego
25-Sep-2006


Page: 1 2 3

Related biology news :

1. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
2. Bacterial response to oxidation studied as toxin barometer
3. Bacterial walls come tumbling down
4. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
5. The results are in: Bacterial parasite strives for balance in host infection
6. Bacterial protein mimics host to cripple defenses
7. Say what? Bacterial conversation stoppers
8. Bacterial cooperation as a target for anti-infectious therapy
9. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
10. Bacterial spread all down to chance: Some strains just the lucky ones
11. OHSU study: Bacterial switching mechanism key to survival

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2019)... ... January 10, 2019 , ... When Dr. James L. Sherley, ... was invited to contribute a chapter to the new book Perinatal Stem Cells: Research ... Asymmetrex’s effort to address a debilitating secret of stem cell medicine. For more ...
(Date:1/7/2019)... ... 07, 2019 , ... Concerto HealthAI, a technology leader in ... oncology and other key therapeutic areas, and its Chief Executive Officer, Dr. Jeff ... spanning the entire healthcare landscape, on January 8, 2019, at 2:30 p.m. in ...
(Date:1/4/2019)... , ... January 03, 2019 , ... Stay on top ... medical device and food industries. Access to all webinars is free, so be sure ... in your field! Visit http://www.xtalks.com to check out our upcoming webinars, or ...
Breaking Biology News(10 mins):
(Date:1/8/2019)... ... January 08, 2019 , ... The American Society of Gene and ... by a selection committee made up of industry leaders identified by the ASGCT board ... are mentored awards created to support ASGCT members designing transformative pilot studies in gene ...
(Date:1/4/2019)... ... January 02, 2019 , ... CellMax Life , a ... blood, has been named as a partner in Medigen Biotech’s upcoming cell therapy ... for cancer treatment, will use CellMax Life’s circulating tumor cell platform CMxTM, in ...
(Date:12/19/2018)... Md. (PRWEB) , ... December 19, 2018 , ... ... for Life Science, announces the validated release of Limfinity® version 7.1. The new ... important technical offering from RURO as 2018 comes to an end. , Validation ...
(Date:12/14/2018)... ... December 14, 2018 , ... ... have been given the green light to immediately begin a clinical patient trial ... The medical devices bureau of Health Canada has granted what is called an ...
Breaking Biology Technology:
Cached News: