HOME >> BIOLOGY >> NEWS
Bacterial walls come tumbling down

structure. They then were able to repeat the feat to reveal the crystal structure of the enzyme combined with the animal antibiotic.

Their findings help reveal how the enzyme prepares to assemble the bacteria's sugar-coating by plucking sugars from a fat-sugar package known as lipid II. The antibiotic, which is another kind of sugar-lipid, probably mimics the lipid II molecule by tucking into a fold in the enzyme and taking up the space needed to bind to lipid II, the researchers believe. "We would like to see the enzyme in a complex with its natural substrates as well as with inhibitors," Lovering said. In the meantime, scientists now have the details of its shape and key contact points between enzyme and antibiotic.

The enzyme structure is the first ever solved of a member of a family of enzymes that remove sugars from lipids and attach them to other sugars. This process is used in a wide range of biochemical reactions, including allergic responses and cell signaling in cancer.


'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
9-Mar-2007


Page: 1 2 3

Related biology news :

1. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
2. Bacterial response to oxidation studied as toxin barometer
3. Bacterial switch gene regulates how oceans emit sulfur into atmosphere
4. Bacterial protein shows promise in treating intestinal parasites
5. The results are in: Bacterial parasite strives for balance in host infection
6. Bacterial protein mimics host to cripple defenses
7. Say what? Bacterial conversation stoppers
8. Bacterial cooperation as a target for anti-infectious therapy
9. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
10. Bacterial spread all down to chance: Some strains just the lucky ones
11. OHSU study: Bacterial switching mechanism key to survival

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2020)... NEW YORK (PRWEB) , ... ... ... global, full-service clinical research organization (CRO) specializing in complex interventional medical device ... as Vice President, Regulatory Strategy. In this newly established role, Dorothy oversees ...
(Date:1/30/2020)... ... January 30, 2020 , ... Accelera Canada , a ... the Canadian market, is pleased to announce that the company has opened the doors ... company launched in 2017. , “We are so thrilled to now have all ...
(Date:1/28/2020)... ... January 28, 2020 , ... Blue ... efficiency, reduce total cost of care, and limit the utilization of high-cost imaging ... group headquartered in San Antonio, Texas specializes in improving care delivery for MSK ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... ... Travel, Law Firm Travel, Technology Industry Travel and Biotech/Healthcare Industry Travel Indexes. , ... Index illustrates the following statistics:, Average airfare price ...
(Date:1/28/2020)... , ... January 28, 2020 ... ... enterprise software solutions for biopharmaceutical R&D, today announced the release of ... Genedata’s focus on supporting the implementation of Multi-Attribute Methods (MAM) for characterizing ...
(Date:1/27/2020)... ... January 27, 2020 , ... ... has secured financing from strategic investors led by Halma plc , a ... investors Sonion, TDF Ventures, GII LLC, and WSJ Joshua Fund. A representative from ...
(Date:1/24/2020)... ... January 24, 2020 , ... Sierra Instruments, global leader in ... controllers ideal for BioPharm OEMS. Sierra also announces RedyCompact™ flow ... instruments employ high-precision MEMS (Micro-Electro Mechanical Systems) technology utilizing an advanced, ultra-stable no-drift ...
Breaking Biology Technology:
Cached News: