HOME >> BIOLOGY >> NEWS
Banding together: RAS signaling of circadian output

In the June 15th issue of G&D, Drs. Jay Dunlap and Jennifer Loros, with colleagues at Dartmouth Medical School, have finally cloned the band gene, and have found that it is an allele of ras-1. This finding posits RAS signaling as a key mediator of circadian output.

The fungus Neurospora crassa is one of the best studied laboratory systems for circadian rhythms. However, over the past 50 years, almost all of the work done on Neurospora has used laboratory strains carrying the band mutation, because it enables researchers to visualize the fungus' daily circadian growth cycles. Research on Neurospora using this strain has contributed to understanding the basis of jet lag as well as some affective disorders.

While the band mutation has facilitated Neurospora clock observation, researchers are only now realizing what protein is encoded by the band gene, and how the subtle nature of the disruption in the band gene affects Neurospora circadian rhythms.

The Dartmouth team demonstrate that the band mutation is a dominant point mutation in ras-1 that causes a slight increase in GTP exchange, and therefore slightly higher activity levels. Says Dunlap, "Understanding the molecular nature of band makes us all look at output from the circadian clock in a different and clearer way. It's been a long time coming."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
14-Jun-2007


Page: 1

Related biology news :

1. Better together: Bacterial endosymbionts are essential for the reproduction of a fungus
2. Flocking together: Study shows how animal groups find their way
3. Endosome-mediated signaling in plants
4. Scientists report new take on sexual signaling
5. Scripps research scientists identify new regulatory mechanism for critical protein signaling domain
6. Scientists unlock mystery of embryonic stem cell signaling pathway
7. Decreased TGF-beta signaling might make you demented
8. U-M study offers new perspective on nitric oxide signaling in rheumatoid arthritis
9. Key molecular signaling switch involved in allergic disease identified
10. Plague agent helps UT Southwestern researchers find novel signaling system in cells
11. New study reveals signaling pathways required for expansion of pancreas stem cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and ... study of SkQ1 ophthalmic solution in patients with moderate to severe Dry ...
(Date:8/21/2020)... ... August 18, 2020 , ... ... today announced that the U.S. Food and Drug Administration (FDA) has approved the ... SBI-101, for the treatment of severe COVID-19. Approval of this IND allows Sentien ...
(Date:8/12/2020)... ... August 11, 2020 , ... Both ... NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary to gain ... and J&J have annual Research and Development spending in excess of US $10 ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to deliver ... “It’s the only technology of its kind on the market and we were pleased ... the protective capacity of traditional cultured ingredients, creating a natural way to extend the ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... announces a significant expansion of laboratory operations through its COVID-19 testing service, ... testing programs. , Bode-CARES provides a turnkey solution that includes ...
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a ... of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. ... lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine ...
(Date:7/1/2020)... ... 29, 2020 , ... MedShift , a leading medical ... many obstacles created as a result of COVID-19. As a provider at the ... practices and medical manufacturers by expanding access to device offerings, technology services, and ...
Breaking Biology Technology:
Cached News: