HOME >> BIOLOGY >> NEWS
Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein

A protein long thought to provide only mechanical support for keeping cells and tissues from literally falling apart turns out to have much wider utility. In a pair of reports, the protein K17 has been found to also influence wound healing and maintain the structural integrity of hair follicles, according to Johns Hopkins researchers.

The wound-healing work, published in the May 18 issue of Nature, sheds light on how the body repairs wounds and may have implications for preventing or treating chronic wounds such as pressure or bed sores arising from long periods of immobility. Along with the pain and scarring, bed sores significantly increase health care costs in nursing homes and hospitals.

A separate report by the same Hopkins group, published in the May 15 issue of Genes and Development, reports a new and different role for the same protein in promoting hair follicle growth, although the investigators were quick to caution that there's nothing in their work - yet - to suggest a way to prevent or cure human baldness.

K17 belongs to a family of proteins known as keratin intermediate filaments, which are part of the cytoskeleton, an intricate network of flexible protein fibers that maintain cell shape and strength. By studying mice genetically engineered to lack K17, the Hopkins researchers discovered that cells need it to turn on signals that lead to the manufacture of new proteins and cell growth when skin is damaged.

"Here we show an entirely novel and possibly independent, nonmechanical function in which these filaments latch onto and regulate cell signaling proteins," says the study's senior author, Pierre A. Coulombe, Ph.D., professor of biological chemistry in the Institute for Basic Biomedical Sciences at Hopkins. "The involvement of K17 in wound healing has not previously been known to influence the making of proteins, and this information has profound implications for our understanding of the role of the cytoskeleton in da
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
17-May-2006


Page: 1 2 3

Related biology news :

1. Novel sugar-to-hydrogen technology promises transportation fuel independence
2. Novel system developed to turn data into real-time, interactive 3-D images
3. Novel strategies for healthy aging
4. Novel salamander robot crawls its way up the evolutionary ladder
5. Novel test identifies lymphoma patients likely to respond to new therapy
6. Novel laboratory technique nudges genes into activity
7. Novel approaches to tackling obesity, cancer and MRSA
8. Novel approach to cancer drug given major boost
9. Novel regulation of the common tumor suppressor PTEN
10. Novel EGFR ectodomain mutations in glioblastoma
11. Novel regulatory mechanism identified for key tumor suppressor p53

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... The research team of The Hong Kong Polytechnic University (PolyU) ... ground breaking 3D fingerprint minutiae recovery and matching technology, pushing contactless ... use in identification, crime investigation, immigration control, security of access and ... ... A research team led by Dr Ajay Kumar ...
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal ... the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and ...
(Date:10/10/2017)... ... October 10, 2017 , ... For ... has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled ... Volunteer Experience from US2020. , US2020’s mission is to change the trajectory of ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
Breaking Biology Technology:
Cached News: