HOME >> BIOLOGY >> NEWS
Bigelow Laboratory Scientists develop new approach to study marine microbes

West Boothbay Harbor, ME (May 21, 2007) -- Drs. Michael Sieracki and Ramunas Stepanauskas, scientists at Bigelow Laboratory, have proven a new approach of obtaining genetic codes of ocean microbes, based on the analysis of individual unicellular organisms.

"The microbes in the oceans control most major chemical cycles in the biosphere, yet we know very little about how they work or who they are. Finding a reliable and economical way of accessing genomes of the uncultured microorganisms is one of the biggest challenges facing environmental microbiologists today", said Dr. Sieracki. Over 99% of the Earths microorganisms cannot be cultivated in laboratory, making their ecological roles, biochemistry and potential practical applications an unresolved mystery. The cutting-edge approach to tackle this enigma, originally developed for the human genome sequencing project, has been sequencing large quantities of short sections of DNA from the extracts of entire microbial communities, and then assembling these sections back into individual genomes by computational means. Unfortunately, the diversity of natural microbial communities proved so incredibly high, that very few genomes could be assembled from even the largest metagenomic studies, consisting of millions of DNA sequences. In a paper published this month in the Proceedings of the National Academy of Sciences, Drs. Stepanauskas and Sieracki propose an alternative to the metagenomic research.

"We present a novel approach to studying metabolic capabilities of the uncultured microbial taxa. Our method is based on fluorescence-activated sorting, whole genome amplification, and multi-locus DNA sequencing of single cells. This allows us to sequence any number of genes in each cell, including those that reveal cells identity and those that tell us what biochemical reactions the cell is capable of performing", said Dr. Stepanauskas.

The publication "Matching phylogeny and metabolism in th
'"/>

Contact: Fran Scannell
fscannell@bigelow.org
207-633-9618
Bigelow Laboratory for Ocean Sciences
21-May-2007


Page: 1 2

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, August 2007
2. Story tips from the Department of Energys Oak Ridge National Laboratory
3. Psychiatric Genomics Center established at Cold Spring Harbor Laboratory
4. Los Alamos National Laboratory making progress in Groundwater Protection Program
5. Jackson Laboratory researcher receives JDRFs Grodsky award
6. Story tips from the Department of Energys Oak Ridge National Laboratory, April 2007
7. Story tips from the Department of Energys Oak Ridge National Laboratory, March 2007
8. Story tips from the Department of Energys Oak Ridge National Laboratory
9. Cold Spring Harbor Laboratory scientists discover new gene that prevents multiple types of cancer
10. Story tips from the Department of Energys Oak Ridge National Laboratory, January 2007
11. Story tips from the Department of Energys Oak Ridge National Laboratory, November 2006

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... SAN DIEGO and SHANGHAI (PRWEB) , ... August ... ... company pursuing novel approaches for the treatment of chronic inflammatory and fibrotic diseases, ... Operating Officer and Vice President of Drug Discovery. , Dr. Canan previously served ...
(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. Crystallography ... X-ray analysis community, presenting current news and crystallographic research. , The latest ...
(Date:8/21/2020)... ... 2020 , ... NDA Partners Chairman Carl Peck, MD ... expertise in clinical trial planning and feasibility, regulatory inspection readiness, and clinical investigator ... career, Mr. Movahhed has helped design and manage oncology, neurology, cardiovascular, and anti-infective ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the ... its Scientific Advisory Board (SAB) to research the medical potential of terpenes and the ... when combined with terpenes. The board is focused on expanding the recently launched line ...
(Date:8/12/2020)... (PRWEB) , ... August 12, 2020 , ... ... Inc. (EMMA International), a global leader in FDA compliance consulting has been ... nation’s fastest-growing private companies. The list represents a unique look at the most ...
(Date:7/31/2020)... ... ... R3 Stem Cell International is now offering patients the opportunity to receive four ... may choose which extremities they would like treated. , Several studies have shown just ... R3 International, umbilical cord tissue is obtained from a lab with a long history ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, ... provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell ... into a strategic partnership whereby Catalent will provide support for the development, manufacturing, ...
Breaking Biology Technology:
Cached News: