rrent as DNA moves through could yield the sequence of bases in the DNA. A Brown University group led by Sean Ling (
Xinsheng_Ling@brown.edu) will present one solution to reading the individual letters of DNA molecules through nanopores even though they are only 4 angstroms apart (N26.10), as well as making addressable nanopores on chips (N26.1). An entire session on nanopore biophysics (H7) includes a number of advances in nanopore technology from leading researchers, such as Cees Dekker of the Delft University of Technology (
dekker@mb.tn.tudelft.nl) who will discuss his group's latest work with artificial nanopores (H7.2). NIST's John J. Kasianowicz (john.kasianowicz@nist.gov), the researcher who first proposed using nanopores for DNA sequencing ten years ago, will also show that the nanopore of a protein secreted by anthrax may provide the basis of new technologies for quickly detecting anthrax in blood samples, measuring the levels of toxins in the body, and studying the effectiveness of therapeutic agents that fight anthrax (H7.1).
ANTI-BROWNIAN TRAP
Nanometer-scale objects, such as proteins and DNA, constantly jiggle around in a liquid solution as they are bombarded by the heat-carrying solvent molecules that surround them. This jiggling, also known as Brownian motion, makes the task of studying nano-objects very difficult: the objects just don't hold still. Conventional laser tweezers can trap objects, but the smaller the object, the brighter the required laser beam, typically harming objects smaller than 200 nm. Adam Cohen of Stanford (aecohen@stanford.edu) will present the Anti-Brownian Electrokinetic (ABEL) trap. It eliminates the Brownian motion of one object in solution, allowing detailed examination of its properties. The ABEL trap works by using a small, non-damaging amount of laser power to track
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Contact: James Riordon
riordon@aps.org
301-209-3238
American Physical Society
17-Mar-2006
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