The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Bioinformatics-related methods are featured in Cold Spring Harbor Protocols

Cold Spring Harbor, NY Large-scale undertakings such as the Human Genome Project have produced massive amounts of data. To make sense of it all, powerful mathematical and statistical algorithms were developed, resulting in the interdisciplinary field called bioinformatics. By probing genome sequence data with in silico tools, biologists can infer the functions of specific genes, evaluate the evolutionary relatedness among species, and identify DNA variants that are predictive of disease. This valuable information can both complement and drive the more traditional laboratory-based experimental studies. This months release of Cold Spring Harbor Protocols highlights two articles that discuss the principles and applications of cutting-edge bioinformatics software programs; both are freely available online (www.cshprotocols.org).

The first freely available article (http://www.cshprotocols.org/cgi/content/full/2007/14/pdb.top17) provides guidance on how to use the BLAST (Basic Local Alignment Search Tool) program. BLAST is the tool that is most commonly used to search large databases for DNA and protein sequences with similarities. The article, intended to be a users guide to BLAST, includes a general overview of its algorithmic basis as well as descriptions of various BLAST programs and their appropriate applications. It will be useful to a wide range of biologists seeking to better understand and apply BLAST to their systems.

The second freely available article describes a computational pipeline that has been optimized to identify DNA variants called SNPs (single-nucleotide polymorphisms) in sequence data from corn. The sequences, generated with cutting-edge technology from 454 Life Sciences, are aligned and anchored to the corn genome using BLAST and cross_match (another computational tool). Then, a third program c
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
2-Jul-2007


Page: 1 2

Related biology news :

1. Rutgers, Penn researchers capture research dollars to improve prostate cancer diagnostic methods
2. Cold Spring Harbor Protocols features methods to understand embryos, clones, stem cells
3. A rainbow of methods promises insights into biological processes and diseases
4. New methods and tools needed to measure exposure to airborne nanomaterials
5. Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses
6. Application of Genomatix in silico methods reveals novel cancer associated genes
7. A frenzy of fruit fly methods featured in Cold Spring Harbor Protocols
8. Plant-derived molecules, genetic manipulation point to future chemoprevention methods
9. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
10. CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
11. Cold Spring Harbor Protocols features methods for analyzing protein interactions

Post Your Comments:
(Date:11/24/2009)...understanding how sounds associated with Navy sona...if they hear it at all. , The same type of large... detect flaws in the space shuttle,s behemoth soli...inside the giant head of a whale. The scans are pr...hale,s hearing anatomy using a breakthrough method...
(Date:11/24/2009)...teries from collapsing have been true life-savers....needed -- once the arteries are strengthened, they...oice but to leave them in place. , Prof. Meital ...iomedical Engineering has developed a new patent-p...y,re needed, then dissolves. , "Our new composit...
(Date:11/24/2009)...dical Toxicology (ACMT) have signed an agreement t...f Medical Toxicology (JMT), the official journal ...iously published by the University of Pennsylvania...an international, peer-reviewed journal, is dedica...al toxicology. The quarterly journal focuses on t...
Breaking Biology News(10 mins):Rocket science leads to new whale discovery 2A coating for life 2Springer and the American College of Medical Toxicology to work together 2Amgen to Discuss Denosumab Data at Todays Advisory Committee for Reproductive Health Drugs 54404 1Amgen to Discuss Denosumab Data at Todays Advisory Committee for Reproductive Health Drugs 54404 2Amgen to Discuss Denosumab Data at Todays Advisory Committee for Reproductive Health Drugs 54404 3Amgen to Discuss Denosumab Data at Todays Advisory Committee for Reproductive Health Drugs 54404 4Amgen to Discuss Denosumab Data at Todays Advisory Committee for Reproductive Health Drugs 54404 5Amgen to Discuss Denosumab Data at Todays Advisory Committee for Reproductive Health Drugs 54404 6Amgen to Discuss Denosumab Data at Todays Advisory Committee for Reproductive Health Drugs 54404 7Spectral announces second quarter 2009 results 13544 1Spectral announces second quarter 2009 results 13544 2Spectral announces second quarter 2009 results 13544 3Spectral announces second quarter 2009 results 13544 4Spectral announces second quarter 2009 results 13544 5Spectral announces second quarter 2009 results 13544 6Spectral announces second quarter 2009 results 13544 7Spectral announces second quarter 2009 results 13544 8Bill 26 Melinda Gates Foundation Appoints Joe Cerrell to Lead New European Office 54399 1Bill 26 Melinda Gates Foundation Appoints Joe Cerrell to Lead New European Office 54399 2Bill 26 Melinda Gates Foundation Appoints Joe Cerrell to Lead New European Office 54399 3
(Date:11/25/2009)...ire/--Reportlinker.comannouncesthatanewmarketresea...ioethanolMarketAnalysisandForecaststo2013 ,, ...anol-Market-Analysis-and-Forecasts-to-2013.html ,...013 ,, Summary ,, Thereportprovidesdetaile...dtheBrazilbioethanolmarketinparticular.Italsohelps...
(Date:11/24/2009)...ire-FirstCall/--IES(Nasdaq: IESC ),aleadingnationa...rvicesforthecommercial,industrialandresidentialmar...asbeenawardedacontractfromManhattanTorconJVtoinsta...L-4)replacementfacilityattheU.S.ArmyMedicalResearc...ickinFrederick,Md. ,, ThenewUSAMRIIDreplacement...
(Date:11/24/2009)...4/PRNewswire/--Twomoreprestigiousuniversitieshavej...ardandcareerssiteforlifescienceprofessionals. ,...thejobboard,joining28othermajorlifesciencetraining...er.com ,isonlyforpost-graduatesinthelifesciences.W...nternet,BioCareerCenteristheonlyonethatserveslifes...
(Date:11/24/2009)...wire-FirstCall/--Sigma-AldrichCorporation(Nasdaq: ...esday,December1stat1:45PMGMTinLondon,7:45AMUS/CST....rtheInternetavailableat http://inve s tor.sig ...ontoaccessthisfile. ,, AboutSigma-Aldrich: S...company.Itschemicalandbiochemicalproductsandkitsar...
Breaking Biology Technology:Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 3Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 4Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 5Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 6Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 7Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 8Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 9Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases 2Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2
Other News:
...ss.--Researchers at MIT and Harvard Medical School...he pathogenic effects of Huntington's disease, a d...reatment for the disease.......There is no cure fo...now afflicts 30,000 Americans, with another 150,00...
A team of researchers at Vanderbilt-Ingram Cancer Center has been awarded $1.5 million from the Susan G. Komen Breast Cancer Foundation, to help fund two studies targeting women at high risk for devel
...t New York University's Center for Comparative Fun... Berkeley have used computational analyses to pred...in the animal model organism, Caenorhabditis elega...mRNA) in a specific section, called 3'UTR, and are...
...t the Salk Institute for Biological Studies have i...that controls the speed with which our leg muscles...ant milestone in understanding the neural circuitr...main obstacles in developing new treatments for sp...
MIT research holds promise for Huntington's treatment 2Vanderbilt-Ingram Cancer Center receives funding for novel breast cancer and obesity studies 2Vanderbilt-Ingram Cancer Center receives funding for novel breast cancer and obesity studies 3Biologists develop genome-wide map of miRNA-mRNA interactions 2Salk researchers make fast strides towards understanding how our body controls walking 2
CHICAGO Who are we and where did we come from? In the quest to answer these fundamental questions about human origins, no one has had a greater or more lasting impact than Louis Leakey (1903-1972). .
... biology student has glanced into a microscope to ...d the like -- being propelled by the waving, hair-...o found in human cells, helping move fluid and muc...sticking out from cells to act like antennae. .......
...ce academies from every continent in the world hav...uman reproductive cloning. The statement was issue...s (IAP), a body representing scientific academies ...ence academies say that therapeutic cloning should...
A new paper published in the Proceedings of the National Academy of Sciences hypothesizes that overfishing of whales in the North Pacific Ocean triggered one of the longest and most complex ecological
Louis Leakey Centennial Tribute 2Louis Leakey Centennial Tribute 3Cellular problem discovered behind syndrome of obesity, learning disabilities 2Cellular problem discovered behind syndrome of obesity, learning disabilities 3International scientific body calls for ban on human reproductive cloning 2Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales 2Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales 3Collapse of seals, sea lions & sea otters in North Pacific triggered by overfishing of great whales 4