HOME >> BIOLOGY >> NEWS
Bioinformatics-related methods are featured in Cold Spring Harbor Protocols

Cold Spring Harbor, NY Large-scale undertakings such as the Human Genome Project have produced massive amounts of data. To make sense of it all, powerful mathematical and statistical algorithms were developed, resulting in the interdisciplinary field called bioinformatics. By probing genome sequence data with in silico tools, biologists can infer the functions of specific genes, evaluate the evolutionary relatedness among species, and identify DNA variants that are predictive of disease. This valuable information can both complement and drive the more traditional laboratory-based experimental studies. This months release of Cold Spring Harbor Protocols highlights two articles that discuss the principles and applications of cutting-edge bioinformatics software programs; both are freely available online (www.cshprotocols.org).

The first freely available article (http://www.cshprotocols.org/cgi/content/full/2007/14/pdb.top17) provides guidance on how to use the BLAST (Basic Local Alignment Search Tool) program. BLAST is the tool that is most commonly used to search large databases for DNA and protein sequences with similarities. The article, intended to be a users guide to BLAST, includes a general overview of its algorithmic basis as well as descriptions of various BLAST programs and their appropriate applications. It will be useful to a wide range of biologists seeking to better understand and apply BLAST to their systems.

The second freely available article describes a computational pipeline that has been optimized to identify DNA variants called SNPs (single-nucleotide polymorphisms) in sequence data from corn. The sequences, generated with cutting-edge technology from 454 Life Sciences, are aligned and anchored to the corn genome using BLAST and cross_match (another computational tool). Then, a third program c
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
2-Jul-2007


Page: 1 2

Related biology news :

1. Rutgers, Penn researchers capture research dollars to improve prostate cancer diagnostic methods
2. Cold Spring Harbor Protocols features methods to understand embryos, clones, stem cells
3. A rainbow of methods promises insights into biological processes and diseases
4. New methods and tools needed to measure exposure to airborne nanomaterials
5. Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses
6. Application of Genomatix in silico methods reveals novel cancer associated genes
7. A frenzy of fruit fly methods featured in Cold Spring Harbor Protocols
8. Plant-derived molecules, genetic manipulation point to future chemoprevention methods
9. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
10. CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
11. Cold Spring Harbor Protocols features methods for analyzing protein interactions

Post Your Comments:
(Date:7/24/2014)... N.J. A yearlong study funded by the New ... Edward J. Bloustein School of Planning and Public Policy ... in Sandy-affected towns are skeptical about the likelihood of ... survey respondents, 45 percent indicated they were "pessimistic" or ... by Superstorm Sandy would be rebuilt better than they ...
(Date:7/24/2014)... team of researchers led by the University of York ... conservation in the Western Indian Ocean. , The ... point to a revolution in the management of marine ... more than 11,000 km in the region now ... are zones of the seas and coasts designed to ...
(Date:7/24/2014)... on his work with a new drug that successfully treated ... Houston has received a $250,000 grant to expand his research ... to treat a wider range of autoimmune diseases., Chandra Mohan, ... Engineering at UH, previously published a study in Arthritis Research ... successfully treated lupus in mice and reduced the number of ...
Breaking Biology News(10 mins):Rutgers study explores attitudes, preferences toward post-Sandy rebuilding 2Western Indian Ocean communities play vital role in conservation 2Biomedical engineer looks at new applications for novel lupus drug 2Biomedical engineer looks at new applications for novel lupus drug 3
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... sophisticated equipment, trained personnel, and detection dogs to ... attacks. A revolutionary new electronic chip with nano-sized ... much easier. , The groundbreaking nanotechnology-inspired sensor, devised ... ,s School of Chemistry and Center for Nanoscience ... Tracense, picks up the scent of explosives molecules ...
(Date:7/24/2014)... yet to materialise. Yet, scientists are making progress ... faster. One such approach relies on quantum dotsa ... an electric field. A new study demonstrates that ... dots (TQDs) with electrical impulses can help better ... TQDs be used as quantum information units, which ...
(Date:7/24/2014)... Although most natural and synthetic processes prefer to ... potential or energyit is within the realm of ... experience constant changes in energy and phases, such ... These conditions allow humans to regulate their body ... rumble with seismic activity. , But even ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
Cached News: