HOME >> BIOLOGY >> NEWS
Bioinformatics-related methods are featured in Cold Spring Harbor Protocols

Cold Spring Harbor, NY Large-scale undertakings such as the Human Genome Project have produced massive amounts of data. To make sense of it all, powerful mathematical and statistical algorithms were developed, resulting in the interdisciplinary field called bioinformatics. By probing genome sequence data with in silico tools, biologists can infer the functions of specific genes, evaluate the evolutionary relatedness among species, and identify DNA variants that are predictive of disease. This valuable information can both complement and drive the more traditional laboratory-based experimental studies. This months release of Cold Spring Harbor Protocols highlights two articles that discuss the principles and applications of cutting-edge bioinformatics software programs; both are freely available online (www.cshprotocols.org).

The first freely available article (http://www.cshprotocols.org/cgi/content/full/2007/14/pdb.top17) provides guidance on how to use the BLAST (Basic Local Alignment Search Tool) program. BLAST is the tool that is most commonly used to search large databases for DNA and protein sequences with similarities. The article, intended to be a users guide to BLAST, includes a general overview of its algorithmic basis as well as descriptions of various BLAST programs and their appropriate applications. It will be useful to a wide range of biologists seeking to better understand and apply BLAST to their systems.

The second freely available article describes a computational pipeline that has been optimized to identify DNA variants called SNPs (single-nucleotide polymorphisms) in sequence data from corn. The sequences, generated with cutting-edge technology from 454 Life Sciences, are aligned and anchored to the corn genome using BLAST and cross_match (another computational tool). Then, a third program c
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
2-Jul-2007


Page: 1 2

Related biology news :

1. Rutgers, Penn researchers capture research dollars to improve prostate cancer diagnostic methods
2. Cold Spring Harbor Protocols features methods to understand embryos, clones, stem cells
3. A rainbow of methods promises insights into biological processes and diseases
4. New methods and tools needed to measure exposure to airborne nanomaterials
5. Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses
6. Application of Genomatix in silico methods reveals novel cancer associated genes
7. A frenzy of fruit fly methods featured in Cold Spring Harbor Protocols
8. Plant-derived molecules, genetic manipulation point to future chemoprevention methods
9. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
10. CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
11. Cold Spring Harbor Protocols features methods for analyzing protein interactions

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/4/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading experts ... so be sure to register today to save your place! Participate in the discussion ... upcoming webinars: , CLINICAL OPERATIONS , August 27 – Friend or Foe? An Assessment ...
(Date:8/1/2019)... ... August 01, 2019 , ... John R. Freeman, CPA, ... MD, PhD, founder and president of BioLabs, which provides premier co-working spaces for life ... to strengthen our ability to forecast and manage growth,” says Fruehauf. “BioLabs has expanded ...
(Date:8/1/2019)... Fla. (PRWEB) , ... July 31, 2019 , ... ... technologies for personalized treatment. Check your local listings for more information. , Factor ... and treatment of cancer and genetic and age-related diseases. This segment of Advancements ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... ... July 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma ... Biotech. The film focuses on regenerative veterinary medicine as a means of improving ... recently included in the Brentwood and Pacific Palisades International Film Festival in Los ...
(Date:6/12/2019)... TOWNSHIP, N.J. (PRWEB) , ... June 12, 2019 ... ... of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device ... with Shanghai Zillion has been signed. The agreement will grant exclusive rights for ...
(Date:6/11/2019)... Va. (PRWEB) , ... June 11, 2019 , ... ... microlearning engagement, and Carilion Clinic, a national leader in opioid treatment, announced today ... virtual care. , Mytonomy recently deployed its virtual care platform at ...
(Date:5/31/2019)... ... May 29, 2019 , ... For many years, the primary forms of ... demand breakthrough therapies. Advances in immuno-oncology have led to the advent of Chimeric Antigen ... engineered T cell receptors known as “CARs”. The CAR enables the final product to ...
Breaking Biology Technology:
Cached News: