HOME >> BIOLOGY >> NEWS
Bioinformatics-related methods are featured in Cold Spring Harbor Protocols

Cold Spring Harbor, NY Large-scale undertakings such as the Human Genome Project have produced massive amounts of data. To make sense of it all, powerful mathematical and statistical algorithms were developed, resulting in the interdisciplinary field called bioinformatics. By probing genome sequence data with in silico tools, biologists can infer the functions of specific genes, evaluate the evolutionary relatedness among species, and identify DNA variants that are predictive of disease. This valuable information can both complement and drive the more traditional laboratory-based experimental studies. This months release of Cold Spring Harbor Protocols highlights two articles that discuss the principles and applications of cutting-edge bioinformatics software programs; both are freely available online (www.cshprotocols.org).

The first freely available article (http://www.cshprotocols.org/cgi/content/full/2007/14/pdb.top17) provides guidance on how to use the BLAST (Basic Local Alignment Search Tool) program. BLAST is the tool that is most commonly used to search large databases for DNA and protein sequences with similarities. The article, intended to be a users guide to BLAST, includes a general overview of its algorithmic basis as well as descriptions of various BLAST programs and their appropriate applications. It will be useful to a wide range of biologists seeking to better understand and apply BLAST to their systems.

The second freely available article describes a computational pipeline that has been optimized to identify DNA variants called SNPs (single-nucleotide polymorphisms) in sequence data from corn. The sequences, generated with cutting-edge technology from 454 Life Sciences, are aligned and anchored to the corn genome using BLAST and cross_match (another computational tool). Then, a third program c
'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
2-Jul-2007


Page: 1 2

Related biology news :

1. Rutgers, Penn researchers capture research dollars to improve prostate cancer diagnostic methods
2. Cold Spring Harbor Protocols features methods to understand embryos, clones, stem cells
3. A rainbow of methods promises insights into biological processes and diseases
4. New methods and tools needed to measure exposure to airborne nanomaterials
5. Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses
6. Application of Genomatix in silico methods reveals novel cancer associated genes
7. A frenzy of fruit fly methods featured in Cold Spring Harbor Protocols
8. Plant-derived molecules, genetic manipulation point to future chemoprevention methods
9. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
10. CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions
11. Cold Spring Harbor Protocols features methods for analyzing protein interactions

Post Your Comments:
(Date:10/14/2014)... – October 14, 2014 – Scientists from The Scripps ... the National Institutes of Health (NIH) to lead an ... hemorrhagic fever disease in Africa. The study aims to ... some patients die, while others survive the inflection. ... the basic mechanism of how Lassa fever virus causes ...
(Date:10/14/2014)... international team of researchers, led by the Chinese Academy ... Nature Genetics a brief genomic history of ... the tomato plant. , The C.M. Rick Tomato Genetics ... in this study by providing seed of both cultivated ... which builds on the first tomato genome sequence completed ...
(Date:10/14/2014)... – Over the past decades, we have seen numerous ... the needs of infants for social contact and stimulation ... thrive. , Infancy and childhood are critical ... A generation of research suggests that enriched environments, full ... cognitive function. In contrast, deprivation and stress may compromise ...
Breaking Biology News(10 mins):Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2Institutional rearing may increase risk attention-deficit disorder 2
(Date:10/18/2014)... October 18, 2014 The Asian arthroscopic ... Asia with analysis and forecast of revenue. The arthroscopic ... $712.3 million by 2018, at a CAGR of 6.5% ... of the Asian arthroscopic devices market, to get an ... a glimpse of the segmentation of arthroscopic devices market ...
(Date:10/18/2014)... NY (PRWEB) October 18, 2014 The ... healthy rate in the five years to 2014. The ... federal renewable energy tax credits that encouraged the use ... enacted renewable portfolio standards (RPSs), which require local utilities ... of their total energy portfolio. Increased campaigning for green ...
(Date:10/17/2014)... engineering professors have received a $451,781 Air Force Office ... at the micro- and nano-scale level that will provide ... professor of Mechanical and Aerospace Engineering, said the new ... than taking X-rays of an aircraft,s wing., "We,ll be ... when we look at it on this scale," Huang ...
(Date:10/17/2014)... October 17, 2014 Bioquell, provider ... upon by health facilities around the world to ... being treated. Among the many places the hydrogen ... Health Presbyterian Hospital Dallas and at the National ... vapor-producing robots have been utilized to decontaminate patient ...
Breaking Biology Technology:The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3UT Arlington project to detect possible damages in aircraft parts early in process 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
Cached News: