HOME >> BIOLOGY >> NEWS
Bioinformatics reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication and they did it solely by computer keystrokes and mouse clicks.

Mikhail Gelfand, a Howard Hughes Medical Institute international research scholar at the Institute for Information Transmission Problems (IITP) in Moscow, and his postdoctoral fellow, Dmitry Rodionov, used comparative genomics to identify a new transcription factor system in bacteria that represses expression of genes involved in DNA replication. They scanned gene sequences and proteomes of several taxonomic groups of bacteria, identifying not only a highly conserved signal sequence, but also the regulatory transcription factor that bound it, the repressor nature of the signal, and other genes also regulated by this system.

"We provided a very detailed description of a system just by doing bioinformatics alone," says Gelfand, director of the IITP's research and training center of bioinformatics. "It's a proof of principle that you can go a very long way by comparative genomics now." Their findings will be published in the July issue of Trends in Genetics, with early publication now online. Gelfand is presenting the work on June 24, 2005, at the annual meeting of HHMI international research scholars in Mrida, Mexico.

Gelfand and Rodionov started their search using a technique called phylogenetic footprinting to review the upstream DNA sequences of a group of genes that code for ribonucleotide reductase enzymes. These enzymes convert the ribonucleotide building blocks of RNA into the deoxyribonucleotides used to build DNA. This conversion is critical for duplicating a bacterium's entire genome before it divides to reproduce.

The search revealed a conserved palindromic sequence occurring upstream of many ribonucleotide reductase (Nrd) genes. A genetic palindrome is a sequence of nucleotides on one strand of DNA that reads the same
'"/>

Contact: Cindy Fox Aisen
aisenc@hhmi.org
317-843-2276
Howard Hughes Medical Institute
22-Jun-2005


Page: 1 2 3

Related biology news :

1. Bioinformatics-related methods are featured in Cold Spring Harbor Protocols
2. Arizona State University hosts Genomes, Evolution, and Bioinformatics conference
3. Oswaldo Cruz Foundation, Virginia Bioinformatics Institute sign agreement...
4. Virginia Bioinformatics Institute to develop Tomato Metabolite Database
5. Virginia Bioinformatics Institute to host international alpha-proteobacteria symposium
6. Virginia Bioinformatics Institute launches microbial database
7. Virginia Bioinformatics Institute researcher receives USDA functional genomics grant
8. Virginia Bioinformatics Institute researcher receives NSF CAREER award
9. Oct. 15-17 Bioinformatics meeting in Irvine, Calif.
10. Satellite tracking reveals threats to Borneo pygmy elephants
11. New technology reveals seal behavior

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/24/2016)... NC (PRWEB) , ... June 24, 2016 , ... Researchers ... the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are ... to read it now. , Diagnostic biomarkers are signposts in the blood, lung ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
Breaking Biology Technology:
Cached News: