HOME >> BIOLOGY >> NEWS
Bioinformatics reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication and they did it solely by computer keystrokes and mouse clicks.

Mikhail Gelfand, a Howard Hughes Medical Institute international research scholar at the Institute for Information Transmission Problems (IITP) in Moscow, and his postdoctoral fellow, Dmitry Rodionov, used comparative genomics to identify a new transcription factor system in bacteria that represses expression of genes involved in DNA replication. They scanned gene sequences and proteomes of several taxonomic groups of bacteria, identifying not only a highly conserved signal sequence, but also the regulatory transcription factor that bound it, the repressor nature of the signal, and other genes also regulated by this system.

"We provided a very detailed description of a system just by doing bioinformatics alone," says Gelfand, director of the IITP's research and training center of bioinformatics. "It's a proof of principle that you can go a very long way by comparative genomics now." Their findings will be published in the July issue of Trends in Genetics, with early publication now online. Gelfand is presenting the work on June 24, 2005, at the annual meeting of HHMI international research scholars in Mrida, Mexico.

Gelfand and Rodionov started their search using a technique called phylogenetic footprinting to review the upstream DNA sequences of a group of genes that code for ribonucleotide reductase enzymes. These enzymes convert the ribonucleotide building blocks of RNA into the deoxyribonucleotides used to build DNA. This conversion is critical for duplicating a bacterium's entire genome before it divides to reproduce.

The search revealed a conserved palindromic sequence occurring upstream of many ribonucleotide reductase (Nrd) genes. A genetic palindrome is a sequence of nucleotides on one strand of DNA that reads the same
'"/>

Contact: Cindy Fox Aisen
aisenc@hhmi.org
317-843-2276
Howard Hughes Medical Institute
22-Jun-2005


Page: 1 2 3

Related biology news :

1. Bioinformatics-related methods are featured in Cold Spring Harbor Protocols
2. Arizona State University hosts Genomes, Evolution, and Bioinformatics conference
3. Oswaldo Cruz Foundation, Virginia Bioinformatics Institute sign agreement...
4. Virginia Bioinformatics Institute to develop Tomato Metabolite Database
5. Virginia Bioinformatics Institute to host international alpha-proteobacteria symposium
6. Virginia Bioinformatics Institute launches microbial database
7. Virginia Bioinformatics Institute researcher receives USDA functional genomics grant
8. Virginia Bioinformatics Institute researcher receives NSF CAREER award
9. Oct. 15-17 Bioinformatics meeting in Irvine, Calif.
10. Satellite tracking reveals threats to Borneo pygmy elephants
11. New technology reveals seal behavior

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) ... international tech event dedicated to developing collaboration between startups and ... on June 15-17. During the event, nine startups will showcase ... value in various industries. France ... the international market, with a 30 percent increase in the ...
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:9/14/2017)... ... September 14, 2017 , ... AIM Global, the worldwide standards ... Inc. has won the 2017 Case Study Competition for AIDC. The award is ... that decrease risk” and push the adoption of automated data collection systems further. ...
(Date:9/13/2017)... ... September 13, 2017 , ... AMRI, a global ... improve patient outcomes and quality of life for more than 25 years, today ... US expert to the International Standards Organization/Technical Committee 194: Biological and Clinical ...
(Date:9/12/2017)... ... 12, 2017 , ... PhysIQ, a Chicago-based company that provides ... monitoring and clinical trial support, earned DPharm Idol 2017 honors at the 7th ... Launched in 2005, PhysIQ leverages artificial intelligence (AI) to empower digital health. The ...
(Date:9/12/2017)... NC (PRWEB) , ... September ... ... Inc. ( http://www.globalspecimensolutions.com ) has announced the release of their latest product ... workflows and storage requirements. LabCODE™ offers pre-built capabilities for Biobanking, Pharmacokinetics, ...
Breaking Biology Technology:
Cached News: