HOME >> BIOLOGY >> NEWS
Bioinformatics reveals new gene regulation system

By comparing 140 sequenced bacterial genomes, researchers have uncovered a system for regulating genes essential to bacterial replication and they did it solely by computer keystrokes and mouse clicks.

Mikhail Gelfand, a Howard Hughes Medical Institute international research scholar at the Institute for Information Transmission Problems (IITP) in Moscow, and his postdoctoral fellow, Dmitry Rodionov, used comparative genomics to identify a new transcription factor system in bacteria that represses expression of genes involved in DNA replication. They scanned gene sequences and proteomes of several taxonomic groups of bacteria, identifying not only a highly conserved signal sequence, but also the regulatory transcription factor that bound it, the repressor nature of the signal, and other genes also regulated by this system.

"We provided a very detailed description of a system just by doing bioinformatics alone," says Gelfand, director of the IITP's research and training center of bioinformatics. "It's a proof of principle that you can go a very long way by comparative genomics now." Their findings will be published in the July issue of Trends in Genetics, with early publication now online. Gelfand is presenting the work on June 24, 2005, at the annual meeting of HHMI international research scholars in Mrida, Mexico.

Gelfand and Rodionov started their search using a technique called phylogenetic footprinting to review the upstream DNA sequences of a group of genes that code for ribonucleotide reductase enzymes. These enzymes convert the ribonucleotide building blocks of RNA into the deoxyribonucleotides used to build DNA. This conversion is critical for duplicating a bacterium's entire genome before it divides to reproduce.

The search revealed a conserved palindromic sequence occurring upstream of many ribonucleotide reductase (Nrd) genes. A genetic palindrome is a sequence of nucleotides on one strand of DNA that reads the same
'"/>

Contact: Cindy Fox Aisen
aisenc@hhmi.org
317-843-2276
Howard Hughes Medical Institute
22-Jun-2005


Page: 1 2 3

Related biology news :

1. Bioinformatics-related methods are featured in Cold Spring Harbor Protocols
2. Arizona State University hosts Genomes, Evolution, and Bioinformatics conference
3. Oswaldo Cruz Foundation, Virginia Bioinformatics Institute sign agreement...
4. Virginia Bioinformatics Institute to develop Tomato Metabolite Database
5. Virginia Bioinformatics Institute to host international alpha-proteobacteria symposium
6. Virginia Bioinformatics Institute launches microbial database
7. Virginia Bioinformatics Institute researcher receives USDA functional genomics grant
8. Virginia Bioinformatics Institute researcher receives NSF CAREER award
9. Oct. 15-17 Bioinformatics meeting in Irvine, Calif.
10. Satellite tracking reveals threats to Borneo pygmy elephants
11. New technology reveals seal behavior

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/23/2017)... March 23, 2017 The report "Gesture Recognition and Touchless ... and Geography - Global Forecast to 2022", published by MarketsandMarkets, the market is ... of 29.63% between 2017 and 2022. Continue Reading ... ... ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel ... came to the DERMALOG stand together with the Japanese Prime Minster Shinzo ... At the largest German biometrics company the two government leaders could see ... as well as DERMALOG´s multi-biometrics system.   Continue ... ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... 20, 2017 , ... USDM Life Sciences , the leading risk management, ... is pleased to announce Holger Braemer as Vice President of its Europe ... in Germany. , Braemer is an integral part of USDM’s expansion of services ...
(Date:4/20/2017)... ... ... Parallel6™ , the leader in mClinical™ technologies for improving patient enrollment, ... of the 2017 Top 10 eClinical Trial Management Solution Providers by Pharma Tech ... take pride in honoring Parallel6 as one of the top 10 companies that are ...
(Date:4/19/2017)... ... April 18, 2017 , ... The Vibrating Orifice Aerosol Generator ... generating monodisperse droplets of known diameters for research applications such as for calibrating ... by drying monodisperse droplets. , The VOAG requires forcing liquid out of ...
(Date:4/19/2017)... (PRWEB) , ... April 19, 2017 , ... ... $1.5M Series A-1 financing round. This event adds to several other early achievements ... its’ Executive and Scientific Teams. , ThermaGenix will use proceeds from ...
Breaking Biology Technology:
Cached News: