Biological importance of basal activity of appetite suppressor

The most frequent genetic cause of obesity in humans is melanocortin-4 receptor (MC4R) mutations. MC4R has an effect on appetite: when MC4R is activated by its ligand amelanocyte-stimulat-ing hormone (a-MHC) appetite is suppressed. When its activity is suppressed by its ligand agouti-related protein (AGRP), appetite is enhanced. MC4R also has a low level activation, resulting in appetite suppression, even in the absence of a-MHC. Given its pivotal role in energy homeostasis, MC4R is considered a viable therapeutic target for combat-ing obesity. The parts of the MC4R protein that is required for a-MHC activation are well known, but those required for its constitutive activity and the biologic importance of this low level of MC4R activity remain uncertain.

To further understanding in these areas, Christian Vaisse and colleagues, from the University of California, San Francisco, made a systematic study of naturally occurring MC4R mutations in obese patients. By genetically transferring normal or mutant versions of the MC4R gene into cells in culture, the authors were able to define a cluster of mutations at the N-terminal end that impaired the constitutive activ-ity of MC4R. Deletion of the N-ter-minal portion of the protein demonstrated that it is required for this basal activity. Further analysis proved that this domain func-tions as an intermolecular self-activating ligand that does not mimic manner in which a-MHC activates MC4R. The work here suggests that in devising therapies for obesity that target MC4R, designing a molecule that provides a low, sustained level of MC4R activation may be a better therapeutic agent for combating obesity than a more powerful activating molecule, which can result in the MC4R receptor becoming desensitized.


Contact: Laurie Goodman
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Story ideas from the Journal of Biological Chemistry
2. News tips from the Journal of Biological Chemistry
3. News tips from the Journal of Biological Chemistry
4. News tips from the Journal of Biological Chemistry
5. Biologically inspired sensors can augment sonar, vision system in submarines
6. Nanotechnology for Biological, Biomedical and Chemical Sensing
7. Biological clock of honey bee more similar to humans than to insects
8. Biological pest control becomes an economic reality
9. Biological diversity and human health; Rapid autopsy program; Snake bites and more
10. Symposium to examine Frontiers in Biological Systems
11. Biological motors sort molecules one by one on a chip

Post Your Comments:

(Date:8/27/2019)... (PRWEB) , ... August 27, 2019 , ... ... company, announced today new opportunities to improve genetic testing guidelines. In the largest ... improve the guidelines to identify more at-risk patients. , Clinicians use guidelines ...
(Date:8/23/2019)... ... August 22, 2019 , ... R121 ... their acquisition in June of 2018. Along with the name change, this rebranding ... “Our goal was to create a cohesive brand that blended our core foundation ...
(Date:8/19/2019)... ... August 19, 2019 , ... Since the microscope was first ... dimensional slices which are placed on microscope slides, stained and visualized by a ... features such as vasculature and thus researchers in the last few years have ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... 10, 2019 , ... An upcoming episode of Advancements with ... genome sequencing analysis. Check your local listings for more information. , Advancements will ... Consulting and will explore its revolutionary pathogenic DNA analysis technology, which predicts in ...
(Date:9/9/2019)... ... September 09, 2019 , ... Visikol CEO Dr. Michael Johnson recently gave a ... best to characterize 3D cell culture models. The inherent problem of characterizing 3D cell ... opaque to image through and therefore traditional wide-field or even confocal microscopy only tells ...
(Date:9/8/2019)... ... 05, 2019 , ... Spartan Bioscience, the leader in on-demand ... Shopify, has been named Chief Financial Officer. , Spartan has also named ... advisors. Additionally, Spartan has hired Steve Edgett as Executive Vice President to lead ...
(Date:9/2/2019)... and LIÉGE, Belgium (PRWEB) , ... September 02, ... ... solutions for epigenetics research and in vitro diagnostics, has launched the industry’s first ... uncover the underlying biological meaning of epigenetic data and other data types. , ...
Breaking Biology Technology:
Cached News: