HOME >> BIOLOGY >> NEWS
Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer

MEDFORD/SOMERVILLE, Mass. In the past ten years, researchers in genome stability have observed that many kinds of cancer are associated with areas where human chromosomes break. They have hypothesized but never proven that slow or altered replication led to the chromosomes breaking.

In a Tufts University study published in the Aug. 3 journal "Molecular Cell," two molecular biologists have used yeast artificial chromosomes to prove the hypothesis. The Tufts researchers have found a highly flexible DNA sequence that increases fragility and stalls replication, which then causes the chromosome to break.

Catherine Freudenreich, associate professor of biology at the School of Arts and Sciences at Tufts University, and doctoral student Haihua Zhang focused on one particular human common fragile site an area that is a normal part of chromosome structure but is prone to breaking. The site lies in the middle of a tumor suppressor gene and chromosome breakage in this area is highly associated with cancer.

"It is an area that has a tumor suppressor gene a gene whose absence can cause tumors," explained Freudenreich. "If you delete that gene or delete part of that gene so it doesn't work anymore, that can lead to tumors. The fact that there is fragility in the same region that this gene is located is a bad coincidence."

"Fragility can cause deletions and deletions can cause cancer, so you want to understand the fragility because that might be what's causing cancer," she continued.

DNA structure leads to fragility

Past research had predicted the flexibility of the DNA helix in this particular common fragile site by calculating the twist angle between consecutive base pairs and found that there were several points of high flexibility, suggesting that the flexibility was connected to the fragility.

Freudenreich and Zhang used yeast artificial chromosomes to test this idea because it allowed them t
'"/>

Contact: Suzanne Miller
suzanne_c.miller@tufts.edu
617-627-4703
Tufts University
2-Aug-2007


Page: 1 2 3

Related biology news :

1. Biologists prove critical step in membrane fusion
2. Biologists call for better choice of model organisms in evo-devo
3. Biologists produce global map of plant biodiversity
4. Biologists develop large gene dataset for rice plant
5. Biologists probe the machinery of cellular protein factories
6. American Society of Plant Biologists Annual Meeting August 5-9 in Boston
7. Biologists find regions of rice domestication
8. How healthy is that marsh? Biologists count parasites
9. Biologists estimate the value of services provided by insects
10. Biologists develop genome-wide map of miRNA-mRNA interactions
11. Biologists visualize protein interaction that may initiate viral infection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/9/2019)... Md. (PRWEB) , ... November ... ... with Alizée Pathology to form the leading provider of specialized histology, pathology, ... research industries. StageBio was recently created by the mergers of Histo-Scientific Research ...
(Date:11/6/2019)... ... November 06, 2019 , ... In October, Massachusetts stem cell ... patients about a poorly disclosed deficiency in stem cell treatments. Throughout stem ... the treating stem cells. This problem affects all patients receiving stem cell ...
(Date:11/5/2019)... ... November 05, 2019 , ... Dr. ... and restorative dentistry to Seattle, WA, including porcelain veneers , smile makeovers, ... from the University of Washington, Dr. Kopp is passionate about serving her Seattle ...
Breaking Biology News(10 mins):
(Date:10/29/2019)... ... October 29, 2019 , ... Modality Solutions, a ... cold chain validation workshop at the Biomanufacturing World Summit (BMWS19) Conference, November 11-12, ... The Biomanufacturing World Summit brings together pharmaceutical executives, cutting-edge technology providers, ...
(Date:10/22/2019)... ... October 22, 2019 , ... Catalent, a global leader ... and Drug Product Technologies Integration, will participate in a panel session titled “Cell and ... be held at the Gwen Hotel, Chicago, on Oct. 28-30, 2019. , The panel ...
(Date:10/17/2019)... ... October 16, 2019 , ... My Gene ... information, has published a new white paper that explores how frequently medical management ... to how patients and medical providers can be kept informed as changes are ...
(Date:10/10/2019)... ... ... R3 Stem Cell announces it has added an exosome presentation to its ... with spots still open. , The speaker, Dr. Ian White PhD, is a world ... Harvard and Dartmouth. He currently serves as the Chief Scientific Officer at IMAC Regeneration ...
Breaking Biology Technology:
Cached News: