HOME >> BIOLOGY >> NEWS
Biologists visualize protein interaction that may initiate viral infection

Biologists at Purdue University have taken a "snapshot" of a Velcro-like protein on a cell's surface just after it attached to the dengue virus, a linkup thought to initiate the early stages of infection.

The virus, which is spread by mosquitoes, infects more than 50 million people annually, killing about 24,000 each year, primarily in tropical regions.

During the earliest stages of infection, the dengue virus attaches to the "carbohydrate recognition domain," or CRD, of a key binding protein called DC-SIGN, located on a host cell's surface.

Using a powerful imaging tool called cryo-electron microscopy, the biologists took a picture of the virus attached to the CRD shortly after the two joined together. It is the first time scientists have visualized the virus and CRD binding.

"We formed the virus-CRD complex, took a snapshot and determined its structure," said Michael Rossmann, the Hanley Distinguished Professor of Biological Sciences in Purdue's College of Science. "Ultimately, researchers might want to find ways to treat or prevent viral infections, but in order to do that we first have to learn how viruses work and how they initiate infection."

The findings are detailed in a research paper to appear on Feb. 10 in the journal Cell. The research was carried out by Elena Pokidysheva and Ying Zhang, post-doctoral research associates working with Rossmann and Richard J. Kuhn, a professor and head of Purdue's Department of Biological Sciences.

Researchers from the Howard Hughes Medical Institute at Columbia University provided a cloned gene that enabled the Purdue scientists to produce the CRD.

The CRD is part of a protein receptor molecule called DC-SIGN - or dendritic cell-specific ICAM3 grabbing non-integrin. ICAM stands for intercellular adhesion molecule, a family of cell proteins that viruses bind to, and the number 3 defines a specific protein.

"The binding occurs on dendritic cells, which are usua
'"/>

Contact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
9-Feb-2006


Page: 1 2 3

Related biology news :

1. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer
2. Biologists prove critical step in membrane fusion
3. Biologists call for better choice of model organisms in evo-devo
4. Biologists produce global map of plant biodiversity
5. Biologists develop large gene dataset for rice plant
6. Biologists probe the machinery of cellular protein factories
7. American Society of Plant Biologists Annual Meeting August 5-9 in Boston
8. Biologists find regions of rice domestication
9. How healthy is that marsh? Biologists count parasites
10. Biologists estimate the value of services provided by insects
11. Biologists develop genome-wide map of miRNA-mRNA interactions

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... solutions for drugs, biologics, cell and gene therapies, and consumer health products, today ... PEGS Boston Virtual Conference & Expo, taking place between Aug. 31 – September ...
(Date:8/21/2020)... ... August 19, 2020 , ... “How can we ... dedicated to Salivary Bioscience for more than twenty years. Together with Douglas Granger, ... " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and Applications ," and Steven ...
(Date:8/12/2020)... , ... August 12, 2020 , ... ... monitoring systems that are ideal for public health agencies of all sizes. With ... diseases and helping at-risk individuals find appropriate health care, Mosio helps public health ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... ... (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical ... team led by Dr MA has been using the zebrafish model to investigate ...
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. (“Lumeda”), ... announced the company has entered a license agreement with Roswell Park Comprehensive Cancer ... exclusive rights to Roswell Park intellectual property surrounding a novel medical device and ...
Breaking Biology Technology:
Cached News: