Biomarkers of response to VEGF pathway-targeted therapy discovered for renal cell carcinoma

CHICAGO -- Angiogenesis inhibitors can be far more effective in treating metastatic clear cell renal cell cancer (RCC) - an aggressive form of the most common kind of kidney cancer that is also rich in blood supply - than traditional treatments, according to accumulating evidence. They can prolong life in about a third of patients, but researchers have not been able to identify the responding patients, prior to treatment.

Now, a research team from the University of California, San Francisco (UCSF) and the Cleveland Clinic, has found that patients whose tumors produce greater amounts of vascular endothelial growth factor (VEGF) and its receptor benefit most from these targeted treatments, because these proteins are the "targets" they are designed to go after.

"The more VEGF and VEGF receptor a patient's tumor has, the better these treatments seem to work," said the study's lead author, Erich B. Jaeger, Ph.D., a postdoctoral researcher at the UCSF Comprehensive Cancer Center. "This is very exciting because, if validated, a fairly simple test could help oncologists direct these new treatments to patients who can benefit most from them."

Results were presented at the first meeting on Molecular Diagnostics in Cancer Therapeutic Development, organized by the American Association for Cancer Research.

Clear cells RCCs often accumulate VEGF and other angiogenesis-related proteins due to mutation in the Von Hippel-Lindau (VHL) tumor suppressor gene. This gene was identified as the cause of the rare and inherited Von Hippel-Lindau disease, which is characterized by frequent development of clear cell renal tumors.

About half of non-inherited clear cell renal cell cancer is believed to result from mutations in the VHL gene, Jaeger said. The mutations prevent proper degradation of specific VHL target proteins, which leads to over-expression of VEGF and other proteins associated with angiogenesis, he said. These proteins cause the t

Contact: Warren Froelich
American Association for Cancer Research

Page: 1 2

Related biology news :

1. Biomarkers may hone anti-aging therapies
2. Biomarkers isolated from saliva successfully predict oral and breast cancer
3. MIT model could predict cells response to drugs
4. Strength of connections between brain regions may affect an adolescents response to peer influence
5. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
6. Identified main genetic variants involved in response to HIV
7. Minister Lunn announces $39.6M for next phase of mountain pine beetle response
8. Columbine flowers develop long nectar spurs in response to pollinators
9. PET accurately identifies esophageal cancer patients positive responses to chemotherapy
10. Every moment counts: Predicting treatment responses earlier for brain tumor patients
11. FDG-PET imaging clearly predicts lung cancer patients response to chemotherapy

Post Your Comments:

(Date:9/11/2019)... ... September 10, 2019 , ... ... Pritha Srinivasan is an unusual collaboration that offers a beautiful and thought-provoking journey ... years where sometimes Srinivasan painted to Whittaker’s poems and other times, Whittaker wrote ...
(Date:8/29/2019)... DIEGO (PRWEB) , ... August 28, 2019 , ... Lajollacooks4u ... The San Diego-based team building and cooking events company has seen record growth in ... Teams, such as Amazon, ServiceNow, Vistage and Illumina, have all visited the company’s La ...
(Date:8/27/2019)... ... August 27, 2019 , ... ... drug development. This episode is scheduled to broadcast 4Q/2019. Check local listings for ... research, development, investment and manufacturing company. The show will highlight how Debiopharm is ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... INDIGO Biosciences, Inc. ... solutions, announced the appointment of Mark McLoughlin to the Company’s Board of Directors. ... McLoughlin will lend his healthcare expertise and extensive background in laboratory and scientific ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... for sales and service organizations, today announced that the company’s Studio Intelligent ... for the IVA market . Inference will officially accept the award at Frost ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast focused on ... SDBN BUZZ podcast will also serve to promote the region and attract external ...
(Date:8/6/2019)... ... 05, 2019 , ... Advanced Clinical, a clinical research services ... by PharmaVOICE magazine, earning him a prestigious spot on the 2019 PharmaVOICE 100 ... , As the executive vice president of business development and marketing at Advanced ...
Breaking Biology Technology:
Cached News: