HOME >> BIOLOGY >> NEWS
Birth defect gene identified

sure proper development. This suggests a potential therapy for embryos that are missing TGF-beta in the neural crest cells.

"This might be useful to try out some possible rescue experiments," Chai said.

Although Chai's current results apply only to mice, a paper last spring in Nature Genetics (Loeys et al., 2005) identified a handful of human families with inherited mutations in TGF-beta receptors and with a high incidence of craniofacial defects, including cleft palate and skull malformations.

If the signaling mechanism in mice were to carry over to humans, pharmaceutical researchers could start to investigate FGF as a potential supplement for pregnant women, analogous to folic acid for prevention of spina bifida.

Chai noted that the FGF supplements in mice restored normal cell growth only in the skull region.

"Using FGF signaling we can actually rescue the cell proliferation defect, but so far we have not been able to do the same thing in the palate," Chai said.

TGF-beta also appears to work through different mechanisms in other parts of the body, Chai added. This suggests that no single treatment can correct all birth defects related to TGF-beta.


'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
22-Dec-2005


Page: 1 2

Related biology news :

1. Birth rate, competition are major players in hominid extinctions
2. Birth defects: 8 million annually worldwide
3. Birth factors associated with risk for autism
4. Birthing a new model of aspirin therapy in preeclampsia
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. Monell researchers find metabolic defect in liver that can lead to obesity
7. Developer of new method for treating bone defects wins WPI Entrepreneurship Award
8. Genetic defect links respiratory disease and congenital heart disease
9. Erectile dysfunction in diabetes is due to selective defect in the brain
10. Transport interrupted -- Texas A&M biologists trace cause of early blindness to tissue defect
11. Joslin researchers discover a surprising culprit in the search for causes of diabetic birth defects

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:6/1/2016)... Favorable Government Initiatives Coupled With ... Identification to Boost Global Biometrics System Market Through 2021  ... report, " Global Biometrics Market By Type, By ... 2011 - 2021", the global biometrics market is projected ... of growing security concerns across various end use sectors ...
(Date:5/12/2016)... DALLAS , May 12, 2016 ... has just published the overview results from the Q1 ... of the recent wave was consumers, receptivity to a ... wearables data with a health insurance company. ... choose to share," says Michael LaColla , CEO ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Cancer experts from Austria, Hungary, Switzerland, and ... new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has just published ... , Biomarkers are components in the blood, tissue or body fluids that ...
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... announced the funding of a Sponsored Research Agreement ... circulating tumor cells (CTCs) from cancer patients.  The ... in CTC levels correlate with clinical outcomes in ... These data will then be employed to support ...
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
Breaking Biology Technology:
Cached News: