Bisphosphonate treatment is associated with jaw bone problems

Patients treated with intravenous bisphosphonates are at an increased risk of jaw or facial bone deterioration or infection, according to a study published online June 26 in the Journal of the National Cancer Institute.

Several recent studies have found an association between the use of intravenous bisphosphonates and osteonecrosis of the jaw or facial bones, a condition in which poor blood supply to the area leads to bone death or deterioration. Bisphosphonates are used to treat cancer-related bone lesions, elevated levels of calcium in the blood, or reduced bone density.

Gregg Wilkinson, Ph.D., of the University of Texas Medical Branch in Galveston and colleagues used data from the Surveillance, Epidemiology, and End Results registry to identify more than 14,000 cancer patients who were treated with either pamidronate or zoledronic acidtwo types of bisphosphonatesand more than 28,000 patients who did not received bisphosphonates.

After six years, about 5.5% of bisphosphonate users had undergone facial or jaw bone surgery or were diagnosed with inflammation of the jaw bone, compared with 0.3% of non-users. From the database, they could not determine for certain whether the bisphosphonates caused the bone problem or if the patients were already predisposed to bone problems. They also found that the use of these drugs increased from 170 patients in 1990 to 5,348 patients in 2003.

Future research should include large clinical trials of intravenous bisphosphonate users who are followed long enough for the development of adverse events such as osteonecrosis of the jaw. Given the increasing use of intravenous bisphosphonate therapy for patients with severe osteoporosis, it is important that patients receiving therapy with both established and new formulations of intravenous bisphosphonates be followed carefully for adverse bone events involving the facial bones that may be indicative of osteonecrosis of the jaw, the a

Contact: Liz Savage
Journal of the National Cancer Institute

Page: 1 2

Related biology news :

1. New system of wastewater treatment could reduce the size of treatment plants by half
2. UCF research links proteins, stem cells and potential Alzheimers treatment
3. Geisinger scientist seeks cure for Lou Gehrigs disease, creating device to find treatment
4. System to analyze beating heart stem cells could lead to heart attack treatments
5. Gene expression pattern could lead to improved treatment of pediatric septic shock
6. Molecular detectors may refine cancer treatment
7. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
8. A new method of adult stem cell growth efficacious in treatment of disorders of the cornea
9. Scientists take next step in understanding potential target for ovarian cancer treatment
10. New treatment model for HIV
11. New research shows vaginal bacteria vary among healthy women, need customized treatment

Post Your Comments:

(Date:5/24/2019)... ... , ... The newest edition of Crystallography Times from Rigaku ... , Crystallography Times is a monthly electronic newsletter published by Rigaku Oxford Diffraction ( ... by presenting the latest news and crystallographic research. , “Crystallography in the News” ...
(Date:5/23/2019)... (PRWEB) , ... May 23, 2019 , ... ... technologies and development solutions for drugs, biologics and consumer health products, is to ... of biologic drugs at the BIO International Convention, which takes place at the ...
(Date:5/22/2019)... ... May 22, 2019 , ... Leak ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ ... Industrial Production Processes (IPP) Ltd has been signed. The agreement will grant ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... TORONTO (PRWEB) , ... May 02, 2019 , ... Stay ... pharma, biotech, medical device and food industries. Access to all webinars is free, so ... stay relevant in your field! , Visit http://www.xtalks.com to see our upcoming ...
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Agents for sales and service organizations, today announced global availability of Inference ... providers and enterprises of all sizes to harness the power of Google’s ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a developer of ... plant expansion to increase production of methylene malonate monomers and oligomers. , The ... Sirrus’ full-scale production facility, which is scheduled to break ground in 2019. “The ...
Breaking Biology Technology:
Cached News: