HOME >> BIOLOGY >> NEWS
Blocking a premature aging syndrome with anticancer drugs

A class of anticancer drugs currently being evaluated in phase 3 clinical trials may also be an effective treatment for Hutchinson-Gilford progeria syndrome (HGPS), a fatal genetic disorder that causes premature aging. If upcoming studies in a HGPS mouse model validate the results of experiments in cultured cells in the laboratory, a clinical trial of these drugs in HGPS children may begin as early as next spring.

Brian Capell, a New York University medical student participating in the Howard Hughes Medical Institute/National Institutes of Health Research Scholars Program and the first author of the study, reported the findings in the August 29, 2005, issue of the Proceedings of the National Academy of Sciences. The HHMI-NIH Research Scholars Program gives outstanding medical and dental students the opportunity to conduct biomedical research under the direct mentorship of senior NIH research scientists.

Although HGPS is a rare disease that affects only one child in 4 million, the disease has received wide publicity due to its striking nature. Children born with HGPS appear normal, but they experience growth retardation and show symptoms of accelerated aging -- namely hair loss, skin wrinkling, and fat loss -- around the first year of age. Accelerated cardiovascular disease also ensues, which typically causes death around age 12.

In 2003, researchers in Francis Collins's lab at the National Human Genome Research Institute discovered that mutations in the lamin A (LMNA) gene cause HGPS. The discovery has prompted renewed interest among researchers to study this rare syndrome.

When Capell entered Collins's lab in July 2004, he immediately set his sights on understanding the molecular basis of HGPS. "What really interested me in this research in the first place were the potential links to aging and atherosclerotic disease," says Capell. Indeed, understanding HGPS at the molecular level may illuminate general processes
'"/>

Contact: Jennifer Donovan
donovanj@hhmi.org
301-215-8859
Howard Hughes Medical Institute
29-Aug-2005


Page: 1 2 3

Related biology news :

1. Blocking beta1-integrin to treat cancer
2. Blocking blood vessels provides new option for large group of advanced lung cancer patients
3. Blocking COX-1 slows tumor growth in mice
4. Blocking PLK-1 to beat bladder cancer
5. Blocking neurodegeneration by radiation and bone marrow transfer prevents inherited glaucoma in mice
6. Blocking cell signaling can stymie viral infections, study shows
7. Blocking cell suicide switch fails to stop prion damage in mouse brains
8. Promising protein may prevent eye damage in premature babies
9. Study assesses lung treatments for premature babies
10. Different approach needed to protect brains of premature infants
11. Improving outcomes in premature births

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues in Regenerative ... Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy ... effective way to complete one? Will the study comply with all FDA requirements? ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for ... minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of ...
(Date:6/28/2020)... ... ... In an upcoming episode scheduled for the fall of 2020, Advancements with ... Check local listings for more info. , Today, the majority of testing is performed ... throughout the country. Results are then available several days later. Now, in an effort ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has ... different materials for use with CRM, neurostimulation, vascular, and related devices. , ... specific design requirements, performance, and cost criteria; especially where solid wire is limited. ...
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from ... Sr. Manager Regulatory Solutions, in a one hour live webinar on Thursday, ... body in China for drugs and medical devices. Specifically, for medical devices, the NMPA ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... announces a significant expansion of laboratory operations through its COVID-19 testing service, ... testing programs. , Bode-CARES provides a turnkey solution that includes ...
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
Breaking Biology Technology:
Cached News: