HOME >> BIOLOGY >> NEWS
Blocking beta1-integrin to treat cancer

Targeting the function of a protein known as beta1-integrin might represent a novel approach to cancer treatment, according to a paper published online in The EMBO Journal this week. Blocking the action of this protein could help to prevent the formation of metastases by reducing tumour cell proliferation and inducing cell senescence.

Integrins are a family of transmembrane receptors that help maintain tissue integrity by attaching cells to the surrounding extracellular matrix and preventing them from migrating around. These proteins are also important for cell survival and proliferation, and have been shown to contribute to tumour progression in several ways.

Angelika Kren and colleagues investigated transgenic mice with insulinomas tumours of pancreatic beta cells, which metastasize in pancreas lymph nodes. When the authors blocked beta1-integrin function in these mice, tumour cells started disseminating into lymphatic blood vessels because they were not attached to anything any more. However, the cells did not elicit metastasis and were unable to form tumours they stopped growing and became senescent.

The authors suggest that the ablation of beta1-integrin function, and the resulting induction of cellular senescence, represent a potential therapeutic goal for the treatment of cancer. Future research should help to identify the molecular players and pathways involved.


'"/>

Contact: Gerhard Christofori
Gerhard.christofori@unibas.ch
41-612-673-562
European Molecular Biology Organization
6-Jun-2007


Page: 1

Related biology news :

1. Blocking a premature aging syndrome with anticancer drugs
2. Blocking blood vessels provides new option for large group of advanced lung cancer patients
3. Blocking COX-1 slows tumor growth in mice
4. Blocking PLK-1 to beat bladder cancer
5. Blocking neurodegeneration by radiation and bone marrow transfer prevents inherited glaucoma in mice
6. Blocking cell signaling can stymie viral infections, study shows
7. Blocking cell suicide switch fails to stop prion damage in mouse brains
8. New system of wastewater treatment could reduce the size of treatment plants by half
9. Brain blood flow gives clues to treating depression
10. UCF research links proteins, stem cells and potential Alzheimers treatment
11. New strategy for treating allergic disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: