HOME >> BIOLOGY >> NEWS
Blocking beta1-integrin to treat cancer

Targeting the function of a protein known as beta1-integrin might represent a novel approach to cancer treatment, according to a paper published online in The EMBO Journal this week. Blocking the action of this protein could help to prevent the formation of metastases by reducing tumour cell proliferation and inducing cell senescence.

Integrins are a family of transmembrane receptors that help maintain tissue integrity by attaching cells to the surrounding extracellular matrix and preventing them from migrating around. These proteins are also important for cell survival and proliferation, and have been shown to contribute to tumour progression in several ways.

Angelika Kren and colleagues investigated transgenic mice with insulinomas tumours of pancreatic beta cells, which metastasize in pancreas lymph nodes. When the authors blocked beta1-integrin function in these mice, tumour cells started disseminating into lymphatic blood vessels because they were not attached to anything any more. However, the cells did not elicit metastasis and were unable to form tumours they stopped growing and became senescent.

The authors suggest that the ablation of beta1-integrin function, and the resulting induction of cellular senescence, represent a potential therapeutic goal for the treatment of cancer. Future research should help to identify the molecular players and pathways involved.


'"/>

Contact: Gerhard Christofori
Gerhard.christofori@unibas.ch
41-612-673-562
European Molecular Biology Organization
6-Jun-2007


Page: 1

Related biology news :

1. Blocking a premature aging syndrome with anticancer drugs
2. Blocking blood vessels provides new option for large group of advanced lung cancer patients
3. Blocking COX-1 slows tumor growth in mice
4. Blocking PLK-1 to beat bladder cancer
5. Blocking neurodegeneration by radiation and bone marrow transfer prevents inherited glaucoma in mice
6. Blocking cell signaling can stymie viral infections, study shows
7. Blocking cell suicide switch fails to stop prion damage in mouse brains
8. New system of wastewater treatment could reduce the size of treatment plants by half
9. Brain blood flow gives clues to treating depression
10. UCF research links proteins, stem cells and potential Alzheimers treatment
11. New strategy for treating allergic disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/27/2019)... ... October 26, 2019 , ... Since 2010, The HOTH has served over ... the success of their clients, they’ve earned a place on the highly-competitive and desirable ... won many additional awards and accolades along the way. , Now, The HOTH ...
(Date:10/26/2019)... ... October 24, 2019 , ... World Cord Blood Day (WCBD) takes place ... midwives to learn about the current and future uses of cord blood stem cells, ... being used to treat and cure over 80 different life-threatening diseases, including leukemia, lymphoma, ...
(Date:10/26/2019)... ... October 25, 2019 , ... ... therapy in La Plata, MD. Orofacial myofunctional disorders (OMDs) are abnormal movement patterns ... and speaks. This can include anything from difficulty swallowing and limited tongue movement ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia Corporation, the global ... today announces that the U.S. Food and Drug Administration (FDA) has granted the ... temporary relief of chronic neck and shoulder pain of musculoskeletal origin. , Erchonia ...
(Date:10/3/2019)... ... October 01, 2019 , ... ... and reset itself, announced the midway point of its randomized research trial for ... study is to measure the efficacy of a non-invasive technology which compares tones ...
(Date:10/3/2019)... ... 02, 2019 , ... Today marked the official launch of ... program outsourcing success by cultivating radical improvements in leadership, staff, and broader project ... Reese, phaseUP™ brings clients deep, broad and unique expertise in the intricacies of ...
(Date:10/3/2019)... ... October 02, 2019 , ... eKare’s inSight® digital 3D imaging and wound ... by the East Midlands Academic Health Science Network (EMAHSN), the innovation arm of the ... by providing support to develop and deploy solutions to the most pressing challenges facing ...
Breaking Biology Technology:
Cached News: