HOME >> BIOLOGY >> NEWS
Blocking neurodegeneration by radiation and bone marrow transfer prevents inherited glaucoma in mice

Bar Harbor, Maine In a discovery that could point to new treatments for a wide range of neurodegenerative diseases, Jackson Laboratory researchers have found that high-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked the development of glaucoma, by preventing neurodegeneration.

Glaucomas are among the most common neurodegenerative diseases, and a leading cause of blindness in the United States. Many patients with glaucoma have high intraocular pressure (IOP), long believed to be a cause of the degeneration of the optic nerve and nerve cells in the retina that leads to vision loss. The standard treatment for glaucoma is reducing the intraocular pressure by medication or surgery.

However, researchers have also observed that some patients with elevated IOP do not develop optic nerve and retinal damage, while others do incur damage despite relatively normal IOP. "It's increasingly clear," says Dr. Simon W.M. John, leader of the Jackson Laboratory research team and a Howard Hughes Medical Institute Investigator, "that multiple mechanisms are at work in this disease."

John and researchers elsewhere have identified several genes associated with glaucomas. They have also developed inherited mouse glaucoma models that reliably develop glaucoma in mid-life. One of these models is the DBA/2J mouse.

The Jackson research team treated 5- to 8-week-old DBA/2J mice with a single, high dose of gamma radiation, together with bone marrow transfer.

When they examined the mice at 12-14 months--an age at which most DBA/2J mice have advanced glaucoma--the researchers were amazed to find that the vast majority of mice did not have glaucoma. There was no detectable loss of the retinal ganglion cells, which typically degenerate in glaucoma.

"It was very surprising and we had to be very careful," John said. "We repeated the experiment two more times with the same results."

The research p
'"/>

Contact: Joyce Peterson
joyce@jax.org
207-288-6058
Jackson Laboratory
10-Mar-2005


Page: 1 2

Related biology news :

1. Blocking beta1-integrin to treat cancer
2. Blocking a premature aging syndrome with anticancer drugs
3. Blocking blood vessels provides new option for large group of advanced lung cancer patients
4. Blocking COX-1 slows tumor growth in mice
5. Blocking PLK-1 to beat bladder cancer
6. Blocking cell signaling can stymie viral infections, study shows
7. Blocking cell suicide switch fails to stop prion damage in mouse brains
8. Early environmental exposure may accelerate age-related neurodegeneration
9. Enhanced environment restores memory in mice with neurodegeneration
10. Salk and Stanford teams join forces to reveal two paths of neurodegeneration
11. Transcription factor proteins role in cell death, neurodegeneration and schizophrenia

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/11/2016)... Calif. , Jan. 11, 2016 Synaptics ... human interface solutions, today announced that its ClearPad ® ... integration (TDDI) products won two separate categories in the ... Mobile Innovator and Best Technology Breakthrough. The Synaptics ® ... cost, a simplified supply chain, thinner devices, brighter displays ...
(Date:1/8/2016)... January 8, 2016 NXTD ), ... WorldVentures ® , a privately held leading direct seller ... Inc. 5000 fastest-growing company announced that on December ... $2 million in Nxt-ID to develop a proprietary new ... Wocket ® , a unique smart wallet that serves ...
(Date:1/7/2016)... Jan. 7, 2016  A United States District Court ... court in the country to interpret a biometric privacy ... go forward against the photo website Shutterfly brought by ... BRIAN NORBERG vs. SHUTTERFLY, INC.; and THISLIFE, INC ... that Shutterfly violates the Illinois Biometric Privacy Act by ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... R&D program for the development of future natural products for ... research and development center in Israel ... Stockton has a variety of products adapted ... active in more than 35 counties worldwide. ... flagship product Timorex Gold ® is used to control ...
(Date:2/5/2016)... Feb. 5, 2016 ATCC, the premier global ... assist the medical and life science researchers that are ... infection.   CDC website . ... Zika virus is a single-stranded RNA virus of the ... Nile, Dengue and Chikungunya Viruses. Zika virus is transmitted ...
(Date:2/4/2016)... CA (PRWEB) , ... February 04, 2016 , ... ... enterprise talent development and compliance training, today announced an interactive FDA compliance ... Playbook™. The RAPS (Regulatory Affairs Professional Society) accredited interactive course on Morf ...
(Date:2/4/2016)... -- Beike Biotechnology, the Shenzhen ... in late 2015 to mark their successful combined efforts ... --> --> The signing, ... Therapy" was hosted by the Shenzhen Cell Bank and ... Beike Biotechnology Co., Ltd. Shenzhen,s ...
Breaking Biology Technology:
Cached News: