HOME >> BIOLOGY >> NEWS
Blocking neurodegeneration by radiation and bone marrow transfer prevents inherited glaucoma in mice

Bar Harbor, Maine In a discovery that could point to new treatments for a wide range of neurodegenerative diseases, Jackson Laboratory researchers have found that high-dose radiation and bone marrow transfer treatments on glaucoma-susceptible mice completely blocked the development of glaucoma, by preventing neurodegeneration.

Glaucomas are among the most common neurodegenerative diseases, and a leading cause of blindness in the United States. Many patients with glaucoma have high intraocular pressure (IOP), long believed to be a cause of the degeneration of the optic nerve and nerve cells in the retina that leads to vision loss. The standard treatment for glaucoma is reducing the intraocular pressure by medication or surgery.

However, researchers have also observed that some patients with elevated IOP do not develop optic nerve and retinal damage, while others do incur damage despite relatively normal IOP. "It's increasingly clear," says Dr. Simon W.M. John, leader of the Jackson Laboratory research team and a Howard Hughes Medical Institute Investigator, "that multiple mechanisms are at work in this disease."

John and researchers elsewhere have identified several genes associated with glaucomas. They have also developed inherited mouse glaucoma models that reliably develop glaucoma in mid-life. One of these models is the DBA/2J mouse.

The Jackson research team treated 5- to 8-week-old DBA/2J mice with a single, high dose of gamma radiation, together with bone marrow transfer.

When they examined the mice at 12-14 months--an age at which most DBA/2J mice have advanced glaucoma--the researchers were amazed to find that the vast majority of mice did not have glaucoma. There was no detectable loss of the retinal ganglion cells, which typically degenerate in glaucoma.

"It was very surprising and we had to be very careful," John said. "We repeated the experiment two more times with the same results."

The research p
'"/>

Contact: Joyce Peterson
joyce@jax.org
207-288-6058
Jackson Laboratory
10-Mar-2005


Page: 1 2

Related biology news :

1. Blocking beta1-integrin to treat cancer
2. Blocking a premature aging syndrome with anticancer drugs
3. Blocking blood vessels provides new option for large group of advanced lung cancer patients
4. Blocking COX-1 slows tumor growth in mice
5. Blocking PLK-1 to beat bladder cancer
6. Blocking cell signaling can stymie viral infections, study shows
7. Blocking cell suicide switch fails to stop prion damage in mouse brains
8. Early environmental exposure may accelerate age-related neurodegeneration
9. Enhanced environment restores memory in mice with neurodegeneration
10. Salk and Stanford teams join forces to reveal two paths of neurodegeneration
11. Transcription factor proteins role in cell death, neurodegeneration and schizophrenia

Post Your Comments:
(Date:8/22/2014)... Calif. Thomson Reuters , a leading source ... researchers at the University of California, Riverside in its ... minds of our times." , To generate the list, ... to identify researchers whose published work has had enormous ... among some 3,200 individuals who published the greatest number ...
(Date:8/22/2014)... Jolla, CA Research presented at the 29th ... being developed by Hera Therapeutics Inc. combats three ... cause 70 percent of all cervical cancer. , ... HTI-1968 blocked the replication of HPV-16, HPV-18 and ... and Thomas Broker, Ph.D., who presented the findings ...
(Date:8/22/2014)... news release is available in French . ... drain of essential nutrients from African soils looming as a ... report released today finds that over the last five years, ... practices that have rejuvenated 1.6 million hectares and helped them ... the Alliance for a Green Revolution in Africa (AGRA) focuses ...
Breaking Biology News(10 mins):5 UC Riverside scientists among world's most influential scientific minds 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 2Effort to confront Africa's soil health crisis helps millions of farmers triple yields 3Effort to confront Africa's soil health crisis helps millions of farmers triple yields 4
(Date:8/21/2014)... , Aug. 21, 2014 Telomere ... of their Nutraceutical "TELO-20 for Dogs" with ... Telomere-lengthening supplement in the world for dogs. Telomeres ... every chromosome in the body. A wealth of ... experts in Telomere Science and Aging, including Nobel ...
(Date:8/21/2014)... 2014  Decision Resources Group finds that the ... and Mexico currently faces ... approved agents, the anticipated label extension of Boehringer ... of emerging biologics will substantially increase the competitiveness ... IL-5 inhibitors will introduce a new dynamic to the ...
(Date:8/21/2014)... YORK , Aug. 21, 2014 ... congratulates Immune Pharmaceuticals Inc., a biotechnology company, on ... Market.  Immune previously traded on OTCQX®, the best ... by OTC Markets Group. Logo - ... Pharmaceuticals on the successful execution of its growth ...
(Date:8/21/2014)... MOUNTAIN VIEW, Calif. , Aug. 21, 2014 ... their properties and behaviors based on external stimuli ... is poised to have a disruptive effect in ... will revolutionize the business landscape by printing objects ... the aerospace and automotive sectors. Logo ...
Breaking Biology Technology:Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4
Cached News: