HOME >> BIOLOGY >> NEWS
Blood's clotting cells harbor 'ticking time bombs,' finding may help extend blood supply

Fragments of cells in the blood known as plateletswhich form blood clots and assist in wound healinghave internal clocks that act like ticking time bombs, predetermining their death from the moment they are born, according to a new study in the March 23 issue of the journal Cell, published by Cell Press.

The researchers said that the findings could have profound implications for the diagnosis and treatment of platelet disorders. Perhaps even more importantly, they said the discovery suggests that chemical treatments that effectively set those clocks back might increase the shelf life of donated blood platelets, which expire after just five days under the storage conditions now required.

The researchers discovered that platelets characteristically short life span, which for humans is 10 days, is set by the amount of a prosurvival protein they contain. As that protein dwindles, its cellular nemesis takes over, causing the specialized clotting cells to commit a programmed form of suicide called apoptosis.

We found that platelets undergo really classical apoptosis, said David Huang of The Walter and Eliza Hall Institute of Medical Research in Australia. Its surprising in many ways because platelets are an unusual cell type that lacks a nucleus. We didnt know what was controlling their life span. Cell nuclei contain the genetic instructions that ultimately direct the activities of other kinds of cells.

The finding has a whole list of potential implications, added study collaborator Benjamin Kile, also of The Walter and Eliza Hall Institute of Medical Research. For us, probably the most important is the possibility for extending platelet life span in blood banks. Such an extension might be achieved by increasing levels of the prosurvival protein, called Bcl-xL, or by blocking its rival death protein, Bak.

If the platelet storage time could be extended from five to eight or 10 days, it would make a lot of difference for
'"/>

Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
22-Mar-2007


Page: 1 2 3

Related biology news :

1. Novel laboratory model reveals clues to how blood starts clotting
2. Protein important in blood clotting may also play a role in fertility
3. Using chemistry to predict the dynamics of clotting in human blood
4. Help for bleeding hearts: New research links a third protein to blood-clotting disorders
5. Polymer aids in blood clotting, pointing way to new treatment
6. UK is first to administer new anti-clotting technology
7. Carbon nanoparticles stimulate blood clotting, researchers report
8. Redesigned protein accelerates blood clotting
9. Genetic variation alters response to common anti-clotting drug
10. Pregnancy complications related to low levels of anticlotting proteins
11. Newly created cancer stem cells could aid breast cancer research

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... ... Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 ... but what is the most effective way to complete one? Will the study ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. ... of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), ... Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, ... glioblastoma—the most common and aggressive adult brain cancer—announced today the appointments of its ... are charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory ... 16 countries, has reached its 20th anniversary of worldwide use. Introduced in the ... top universities including University of Pennsylvania, University of Michigan, University of Maryland, University ...
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 16, 2020 , ... After ... begins. The completion of a great surgery is only the beginning of a successful ... the research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/18/2020)... ... , ... dicentra , a leading Contract Research Organization ... pleased to announce that Charles Galea has joined its clinical trials division as ... accomplished and results-driven sales executive with over 10 years of expertise in business ...
Breaking Biology Technology:
Cached News: