Blood's clotting cells harbor 'ticking time bombs,' finding may help extend blood supply

Fragments of cells in the blood known as plateletswhich form blood clots and assist in wound healinghave internal clocks that act like ticking time bombs, predetermining their death from the moment they are born, according to a new study in the March 23 issue of the journal Cell, published by Cell Press.

The researchers said that the findings could have profound implications for the diagnosis and treatment of platelet disorders. Perhaps even more importantly, they said the discovery suggests that chemical treatments that effectively set those clocks back might increase the shelf life of donated blood platelets, which expire after just five days under the storage conditions now required.

The researchers discovered that platelets characteristically short life span, which for humans is 10 days, is set by the amount of a prosurvival protein they contain. As that protein dwindles, its cellular nemesis takes over, causing the specialized clotting cells to commit a programmed form of suicide called apoptosis.

We found that platelets undergo really classical apoptosis, said David Huang of The Walter and Eliza Hall Institute of Medical Research in Australia. Its surprising in many ways because platelets are an unusual cell type that lacks a nucleus. We didnt know what was controlling their life span. Cell nuclei contain the genetic instructions that ultimately direct the activities of other kinds of cells.

The finding has a whole list of potential implications, added study collaborator Benjamin Kile, also of The Walter and Eliza Hall Institute of Medical Research. For us, probably the most important is the possibility for extending platelet life span in blood banks. Such an extension might be achieved by increasing levels of the prosurvival protein, called Bcl-xL, or by blocking its rival death protein, Bak.

If the platelet storage time could be extended from five to eight or 10 days, it would make a lot of difference for

Contact: Erin Doonan
Cell Press

Page: 1 2 3

Related biology news :

1. Novel laboratory model reveals clues to how blood starts clotting
2. Protein important in blood clotting may also play a role in fertility
3. Using chemistry to predict the dynamics of clotting in human blood
4. Help for bleeding hearts: New research links a third protein to blood-clotting disorders
5. Polymer aids in blood clotting, pointing way to new treatment
6. UK is first to administer new anti-clotting technology
7. Carbon nanoparticles stimulate blood clotting, researchers report
8. Redesigned protein accelerates blood clotting
9. Genetic variation alters response to common anti-clotting drug
10. Pregnancy complications related to low levels of anticlotting proteins
11. Newly created cancer stem cells could aid breast cancer research

Post Your Comments:

(Date:5/28/2020)... ... May 28, 2020 , ... ... solution for adjunct liquefaction: AMYLEX® 6T. The innovative enzyme enables numerous business ... new segments with locally-sourced raw materials, improve productivity, maximize yield, ensure consistent ...
(Date:5/26/2020)... (PRWEB) , ... May 26, ... ... of enterprise software solutions for biopharmaceutical R&D, today announced that Gritstone Oncology, ... T-cell receptor (TCR)-mimetic bispecific T cell engagers and TCR-based therapeutics, has implemented ...
(Date:5/21/2020)... ... May 21, 2020 , ... ... services specializing in background and medical screening, announces the launch of a ... keeping their workforce safe. The new service is provided by ClearStar’s Medical ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... , ... July 16, 2020 , ... “We are thrilled ... Wave Bioactives. “It’s the only technology of its kind on the market and we ... onions with the protective capacity of traditional cultured ingredients, creating a natural way to ...
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
(Date:7/7/2020)... BOSTON (PRWEB) , ... July 06, 2020 , ... ... Innovative Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of ... Since 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples ...
(Date:6/28/2020)... Calif. (PRWEB) , ... June 25, 2020 , ... The ... the launch of Safe Space™ for businesses of all types to ensure cleanliness, distancing ... LiDAR. , A Safe Space™ enabled business will provide a health performance ...
Breaking Biology Technology:
Cached News: