HOME >> BIOLOGY >> NEWS
Boosting blood vessels with BDNF

When an artery or blood vessel is blocked or narrowed, the consequence is decreased blood flow, and therefore decreased oxygen, to the target organ. This is called ischemia and can result in serious, permanent damage. A goal in ischemia therapy is to induce formation of new blood vessels (called angiogenesis) in order to revascularize an area (neovascularization), be it the heart, the limbs, the brain, or some other organ.

The most widely used agents to promote angiogenesis are growth factors known as VEGF and FGF. However, in clinical settings, these have only been able to form new and stable blood vessels for a limited time. VEGF may also cause abnormal vascular leaks and aberrant masses of blood vessels. Recently, another factor a neurotrophic factor called BDNF (brain derived neurotrophic factor) has been shown to regulate the vasculature of the developing heart, but the mechanism for this interesting action was unclear.

In the March 1 issue of the Journal of Clinical Investigation, Shahin Rafii and Barbara Hempstead along with colleagues from Cornell University, delve into the mechanisms underlying the angiogenic effects of BDNF in adult blood vessels.

The researchers show that BDNF and VEGF have comparable efficacy in inducing growth of tiny blood vessels in organs that contain cells that express the BDNF receptor TrkB. The also show that BDNF is as effective as VEGF in promoting recovery of the blood flow and vessel density in ischemic limbs. BDNF has local effects on TrkB expressing cells and also recruits a subset of blood stem cells that contribute to neo-angiogenesis. This special population of cells responds specifically to BDNF and contributes to neovascularization.

In an accompanying commentary, Dan Duda and Rakesh Jain write, "This work establishes that neurotrophins are novel proangiogenic factors. Understanding the molecular and cellular underpinnings of this interaction may prove to be crucial for both reg
'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Mar-2005


Page: 1 2

Related biology news :

1. Boosting key milk nutrients may help lower type 2 diabetes risk
2. Boosting key milk nutrients may protect against cancer
3. Boosting brain power -- with chocolate
4. Boosting killer cells might improve breast-cancer drug
5. Boosting newborns immune responses
6. Boosting the BCG vaccine to beat tuberculosis
7. Boosting vitamin C in plants can help reduce smog damage
8. High blood pressure, low energy -- a recipe for heart failure
9. Brain blood flow gives clues to treating depression
10. Study finds gender differences in renal and other genes contributing to blood pressure
11. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: