HOME >> BIOLOGY >> NEWS
Botulism bug has few genome wrinkles

The genome of the organism that produces the world's most lethal toxin is revealed today. This toxin is the one real weapon in the genome of Clostridium botulinum and less than 2 kg - the weight of two bags of sugar - is enough to kill every person on the planet. Very small amounts of the same toxin are used in medical treatments, one of which is known as Botox.

The genome sequence, reported in Genome Research, shows that C. botulinum doesn't have subtle tools to evade our human defences or tricky methods of acquiring resistance to antibiotics. It lives either as a dormant spore or as a scavenger of decaying animal materials in the soil, and doesn't interact with human or other large animal hosts for prolonged periods of time.

Occasionally it gets into a living animal, via contaminated food or open wounds, leading to infant botulism or wound botulism, both of which are serious human infections. The host can be quickly overpowered and, in some cases, killed by the toxin, and C. botulinum has a new food source.

"Although in the same group as Clostridium difficile - the Cdiff superbug - C. botulinum has a genome that is remarkable because it is so stable, "commented Dr Mohammed Sebaihia, lead author on the paper from the Wellcome Trust Sanger Institute. "Unlike Cdiff, in which more than 10% of genes have been acquired from other bacteria, there is almost no footprint of these in C. botulinum."

There are several types of C. botulinum: although described as variants of a single species, they are really very different organisms linked simply because they have the deadly toxin. For each type, there is also a near-identical but harmless relative that lacks the toxin. C. sporogenes is the non-malignant, near twin of the organism sequenced.

Professor Mike Peck, from the Institute of Food Research, commented that "It is astonishing that 43% of the predicted genes in the C. botulinum genome are absent from the other five seq
'"/>

Contact: Don Powell
don@sanger.ac.uk
44-012-234-94956
Wellcome Trust Sanger Institute
23-May-2007


Page: 1 2 3

Related biology news :

1. Botulism study could lead to new vaccines and treatments to counter bioterrorist attacks
2. Botulism bug says no to nitric oxide, provides key to molecules role in human cell signaling
3. Unravelling new complexity in the genome
4. One species, many genomes
5. First genome-wide study of infectious disease opens new avenues for HIV treatment, vaccines
6. Charting ever-changing genomes
7. Neutral evolution has helped shape our genome
8. Sea anemone genome provides new view of our multi-celled ancestors
9. Cloning the male genome may help infertile men
10. Mutating the entire genome
11. Exploring the dark matter of the genome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2020)... (PRWEB) , ... February 06, 2020 , ... ... to facilitate access to unique lab-made bioresearch materials, today announced an agreement with ... and plant-based meat and seafood a reality. Under the partnership, terrestrial meat and ...
(Date:2/5/2020)... ... February 05, 2020 , ... LabKey has ... efficiency and insight to sample processing within laboratories. , Built with input ... research in various fields, LabKey Sample Manager has been designed with an intuitive ...
(Date:1/30/2020)... (PRWEB) , ... January 30, 2020 , ... Accelera ... an eye on the Canadian market, is pleased to announce that the company has ... growth since the company launched in 2017. , “We are so thrilled to ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... Calif. (PRWEB) , ... January 24, 2020 , ... ... launch of their RedySmart™ mass flow meters and controllers ideal for ... as an ideal upgrade to antiquated rotameters. These thermal instruments employ high-precision MEMS ...
(Date:1/22/2020)... FARMINGTON, Conn. (PRWEB) , ... January 21, 2020 , ... ... Cell (CTC) liquid biopsy from a simple blood draw, today announced the sale of ... UConn Health. The Rare Scope will be used in clinical cancer research. , “The ...
(Date:1/8/2020)... ... January 08, 2020 , ... ... helps couples and individuals grow their family, has announced that five of their ... Castle Connolly. Since 1991, the renowned publishing company Castle Connolly has ...
(Date:1/7/2020)... ... 2020 , ... ABCT , the Accelerator for Biosciences ... participate in the annual program. Twelve ventures will participate in the 6.5-month-long program ... All startups will receive an entrepreneur coach, access to active business professionals and ...
Breaking Biology Technology:
Cached News: