HOME >> BIOLOGY >> NEWS
Botulism study could lead to new vaccines and treatments to counter bioterrorist attacks

o its specific protein receptor on the surface of a neuron.

The scientists discovered that the neurotoxin works by taking advantage of the neuronal signaling system in which tiny protein-lipid sacs (synaptic vesicles) carry chemical messages (neurotransmitters) from inside the nerve cell to the surface where the neurotransmitters are released. The vesicles then are reprocessed inside the neuron and replenished with neurotransmitters.

The researchers found that botulinum disrupts this process by recognizing and binding to a specific protein receptor, called synaptotagmin, which is an important component of synaptic vesicles. Botulinum neurotoxin basically hijacks synaptotagmin in order to get inside the neuron, Brunger explained. Once inside, the vesicle releases the neurotoxin, which has the devastating effect of blocking the release of acetylcholine, a neurotransmitter that signals the muscle to contract.

The Brunger team also was surprised to discover that the toxicity of botulinum can be dramatically reduced by altering just one amino acid in its molecular structure. This finding suggests the possibility of designing a specific inhibitor that will prevent the neurotoxin from binding to the neuron surface.

Experimental therapies

In addition to treating botulism, the scientists said that their new findings may lead to novel remedies for several neuromuscular conditions, including uncontrolled blinking (blepharospasm), lazy eye (strabismus), involuntary neck muscle contractions (cervical dystonia) and even symptoms of cerebral palsy. Botulinum neurotoxins have become powerful therapeutic tools in the treatment of neurological, ophthalmic and other disorders caused by abnormal, excessive or inappropriate muscle contractions, Brunger said. Experimental studies are also under way that explore their use in managing chronic pain, such as headaches and migraines. Our work also may lead the way to designing modified neurotoxins as a drug d
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
831-915-0088
Stanford University
13-Dec-2006


Page: 1 2 3

Related biology news :

1. Botulism bug has few genome wrinkles
2. Botulism bug says no to nitric oxide, provides key to molecules role in human cell signaling
3. New study warns limited carbon market puts 20 percent of tropical forest at risk
4. Clones on task serve greater good, evolutionary study shows
5. Pollution causes 40 percent of deaths worldwide, study finds
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. New study suggests Concord grape juice may provide protection against breast cancer
8. Preclinical study links gene to brain aneurysm formation
9. In limiting life span, study finds booming bacteria innocent
10. Multicenter study nets new lung tumor-suppressor gene
11. MIT study: Maturity brings richer memories

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... company announced a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide ... clients to strengthen their laboratory supply chain for more than 10 years. Early ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... effectiveness of the Invictus Medical Neoasis™ active noise control device to attenuate typical ... that the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and ...
(Date:7/4/2020)... ... , ... Aesthetics Biomedical (ABM), a leading aesthetics product development ... the products and treatments developed, but also the dedicated team behind the brands ... built by ABM have received several honors already for 2020, each of which ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... up to three different materials for use with CRM, neurostimulation, vascular, and related ... materials to meet specific design requirements, performance, and cost criteria; especially where solid ...
(Date:7/22/2020)... TORONTO (PRWEB) , ... July 22, 2020 , ... Join ... and John Lorenc, Sr. Manager Regulatory Solutions, in a one hour live webinar ... is the regulating body in China for drugs and medical devices. Specifically, for medical ...
(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... testing services and products, announces a significant expansion of laboratory operations through its ... collection for agencies implementing testing programs. , Bode-CARES provides a ...
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
Breaking Biology Technology:
Cached News: