HOME >> BIOLOGY >> NEWS
Brain-injury rehabilitation depends on acetylcholine circuitry

The ability of the brain to recover from such injury as stroke or trauma depends on a particular circuitry of neurons that "talk" to one another using the brain chemical acetylcholine, researchers led by James Conner and Mark Tuszynski in the Neural repair Group at UCSD have discovered. Their finding in rats could help enhance rehabilitation to recover from such injuries by leading to the development of drugs or other treatments to enhance the "cholinergic system."

The researchers said that their finding that the cholinergic system is involved in brain recovery is particularly intriguing in light of the fact that deficits in the system have been associated with aging, Alzheimer's disease, and traumatic brain injury.

Researchers have long believed that rehabilitation from brain injury causes a rewiring, or plasticity, of brain circuitry--called a "reorganization of cortical motor representations"--to reestablish connections that control muscles. However, the specific type of brain circuitry on which this plasticity depended was not known.

Conner and his colleagues were guided in their experiments by earlier studies showing that the cholinergic system in a region called the basal forebrain was associated with normal learning of motor control.

To determine whether this same system also played a role in rehabilitation from brain injury, they first taught rats to reach for food pellets with their forepaws. In one group of animals, they then used a toxin to specifically eliminate cholinergic nerves connecting to the motor and sensory regions of the animals' cortex. The other control group received a sham injection. The researchers then used electrical probes to create small lesions in the rats' brain region responsible for controlling limb movement.

They then gave the rats rehabilitation training. The control group of rats recovered about 55% of the deficit in their reaching ability, while the rats lacking a cholinergic system recov
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
20-Apr-2005


Page: 1 2

Related biology news :

1. Pediatric center to offer novel rehabilitation approach for spinal cord injury
2. Bacteria for better ice cream and artificial snow no longer depends on trek to poles
3. Persistence of HPV infection depends on a patients race
4. Preventing ventilation induced lung injury depends on giving the right number of sighs
5. Cell survival depends on chromosome integrity
6. Difference in talking louder, talking over noise depends on verbal cues, internal targets
7. Fats fate depends on its source
8. Experience sculpts brain circuitry to build resiliency to stress
9. UT Southwestern researchers find alterations in brains circuitry caused by cocaine
10. New study to explore cellular circuitry
11. Nicotine triggers the same brain reward circuitry as opiates

Post Your Comments:
(Date:8/19/2014)... of Texas Health Science Center at San Antonio and ... announced the awarding of more than $750,000 in grants ... Challenge. , Launched in 2003, SALSI is a model ... academic health science center join forces for greater research ... studies, with a focus on public health issues and ...
(Date:8/19/2014)... a nearly $40,000 grant from the National Center for ... National Park Service (NPS) and U.S. Department of the ... the energy efficiency and cost effectiveness of radiant barrier ... Radiant barriers are reflective thermal insulations commonly fitted into ... the amount of heat emitted in the direction of ...
(Date:8/19/2014)... Rochelle, August 19, 2014A new ovoid structure discovered in ... clay, contains a variety of minerals, and shows evidence ... resulting melting of the permafrost and mixing of surface ... broad range of analytical studies to determine the origin ... for how this ovoid formed, point to the most ...
Breaking Biology News(10 mins):San Antonio Life Sciences Institute awards $750,000 to innovators 2San Antonio Life Sciences Institute awards $750,000 to innovators 3UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 2UTSA researcher awarded $38K+ to evaluate energy efficiency options for historic homes 3Life on Mars? Implications of a newly discovered mineral-rich structure 2
(Date:8/18/2014)... Global HIV Infection Drug Market and ... Reportstack. The rate of HIV infection and the number of ... at a positive rate across the globe. It has been ... 2005 to 1.5 in 2013, with the rates for children ... changes in the infection rates has been the improved access ...
(Date:8/18/2014)... , Aug. 18, 2014 TNI BioTech, ... company pioneering the manufacturing and marketing of innovative therapies ... the Company is providing a second notice of TNI ... In making the announcement, Noreen Griffin , founder ... in advance for your participation in the Annual Meeting. ...
(Date:8/18/2014)... , 18. August 2014 Vier ... eine internationale klinische Studie auf, in der ... Linse soll das Sehvermögen bei allen Entfernungen ... Operation möglicherweise keine Lese- oder Gleitsichtbrille mehr ... Namen FluidVision Accommodating Intraocular Lens ...
(Date:8/16/2014)... Laser physicists have found a way to make atomic-force ... detecting forces as small as the weight of an ... The Australian National University (ANU), hinges on using laser ... degrees Celsius. , "The level of sensitivity achieved after ... weight of a large virus that is 100 billion ...
Breaking Biology Technology:Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 2Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 3Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 4Laser makes microscopes way cooler 2
Cached News: