HOME >> BIOLOGY >> NEWS
Brain-mapping technique aids understanding of sleep, wakefulness

DALLAS April 21, 2005 The power of a new technique to map connections among nerve cells in the brain has a UT Southwestern Medical Center scientist dreaming of solving the mysteries of sleep.

By tracking which nerve cells in the mouse brain stimulate others, researchers in Japan and at UT Southwestern found that a type of neuron responsible for keeping animals awake receives inhibitory signals from neurons active only during sleep, as well as reinforcing, positive signals from nerve cells that are very active during wakefulness.

The findings, available online and appearing in the April 21 issue of the journal Neuron, shed light on the complex mechanisms involved in sleep regulation and may help to explain why once a person wakes up and moves around, he tends to stay awake.

"We all know subjectively and objectively that there is a very strong force regulating sleep, but there is very little knowledge about the actual biological mechanism controlling sleep," said Dr. Masashi Yanagisawa, professor of molecular genetics at UT Southwestern and senior author of the study. "Eventually my dream is to elucidate all the pathways regulating sleep."

Dr. Yanagisawa and his colleagues focused on neurons in the brain that produce the protein orexin, which helps keep animals awake. In humans, a lack of, or deficiency in, orexin causes narcolepsy, a rare disease in which people uncontrollably fall asleep, have excessive daytime sleepiness and experience sudden muscle weakness called cataplexy.

Because orexin-producing neurons play such a key role in regulating sleep, determining how they are connected to other neurons in the brain is an important step toward understanding how and why we sleep.

Mapping the neurons to which orexin neurons send signals has been relatively easy, Dr. Yanagisawa said, but determining which neurons send signals to orexin neurons has been a challenge. A brain-mapping technique developed recently by French scientists
'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
21-Apr-2005


Page: 1 2 3

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Innovative research technique reveals another natural wonder in Yellowstone Park
3. New techniques redefine assessment of liver disease
4. New technique will produce a better chromosome map
5. Researchers develop technique for bacteria crowd control
6. Bioluminescence at the service of a novel cerebral imaging technique
7. Natural antibiotics yield secrets to atom-level imaging technique
8. New imaging technique tracks traffic patterns of white blood cells
9. Vet College gets grant to develop fish virus diagnostic technique
10. Harvard team creates spray drying technique for TB vaccine
11. Novel laboratory technique nudges genes into activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/22/2020)... ... April 21, 2020 , ... ... leveraged venture capital firm that provides patent development support for early stage startups. ... treat illnesses such as ovarian cancer and precancerous pancreatic lesions with simple, accurate ...
(Date:4/18/2020)... ... April 16, 2020 , ... SIRION Biotech GmbH , a world ... it will present a company update on its work expediting gene therapy research and ... on April 22 and 23. Dieter Lingelbach, the Company’s Chief Operating Officer, will also ...
(Date:4/16/2020)... ... April 15, 2020 , ... RoosterBio ... and hMSC bioprocess systems, announces that the Medical Technology Enterprise Consortium (MTEC) recognized ... Annual Membership Meeting in March. The Regenerative Medicine (RegenMed) biomanufacturing collaboration had created ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 12, 2020 , ... NanoString Technologies , ... thousands of industry leaders, clinicians, research scientists, medical professionals and academics from around ... MD, Director of the Center for Cellular Immunotherapies at the Perelman School of ...
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages of drug discovery ... no information on the drug’s mechanism of action (MOA). Gene expression profiling technologies ... the activity of molecular pathways. This information can complement phenotypic readouts and can ...
(Date:5/5/2020)... ... May 04, 2020 , ... ... the life sciences industry, today announced that Informa Training Partners, a life sciences ... name to Red Nucleus Boston, effective immediately. , “The name change solidifies a ...
(Date:5/5/2020)... ... May 05, 2020 , ... ... today the launch of its iGlucose® LTE Cat-M Cellular Connected Diabetes ... LTE Cat-M1 technology, the industry’s newest and broadest cellular connectivity available, to provide ...
Breaking Biology Technology:
Cached News: