HOME >> BIOLOGY >> NEWS
Brain-mapping technique aids understanding of sleep, wakefulness

provided Dr. Yanagisawa and his research group new hope for navigating the neural network.

The technique involves genetically engineering mice to produce a "tracer" protein only in a certain population of neurons. The tracer, a nontoxic fragment of the tetanus toxin, transfers itself from one neuron in retrograde fashion to neurons "upstream" -- those from which the tracer-producing neuron receives signals. Researchers then track the tracer to map the upstream neurons.

Dr. Yanagisawa and his colleagues are the first to apply the technique in order to study a specific neural pathway. They introduced the tracer into mice so that it was expressed only in orexin neurons, which are found in a part of the brain called the lateral hypothalamus. The researchers found that some of the upstream neurons in the anterior hypothalamus, known to be active only during sleep, send inhibitory signals to orexin neurons preventing them from releasing orexin.

"Neurons producing orexin keep you awake, and they also stabilize wakefulness," Dr. Yanagisawa said. "In order to fall sleep, you somehow must inhibit these orexin neurons. It appears that sleep-active neurons in a specific region of the brain are doing just that, keeping the animals asleep."

The researchers also found that during wakefulness, orexin neurons activate cells in other parts of the brain that negatively feed back to the sleep-active neurons in the anterior hypothalamus, keeping them from becoming active.

"This makes perfect sense," said Dr. Yanagisawa, a Howard Hughes Medical Institute investigator at UT Southwestern. "When one group of neurons is active, the other group must be inactive, and vice versa. It's a seesaw, or flip-flop, mechanism. That's important because you don't want to be half-asleep. You want to be either completely awake or completely asleep."

Another finding from the Neuron study may help explain why once you're awake and moving around, you tend to stay awake,
'"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
21-Apr-2005


Page: 1 2 3

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Innovative research technique reveals another natural wonder in Yellowstone Park
3. New techniques redefine assessment of liver disease
4. New technique will produce a better chromosome map
5. Researchers develop technique for bacteria crowd control
6. Bioluminescence at the service of a novel cerebral imaging technique
7. Natural antibiotics yield secrets to atom-level imaging technique
8. New imaging technique tracks traffic patterns of white blood cells
9. Vet College gets grant to develop fish virus diagnostic technique
10. Harvard team creates spray drying technique for TB vaccine
11. Novel laboratory technique nudges genes into activity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
(Date:3/23/2016)... March 23, 2016 ... Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender Anbieter ... Unternehmen mit SpeechPro zusammenarbeitet, um erstmals dessen ... wird die Möglichkeit angeboten, im Rahmen mobiler ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
Breaking Biology Technology:
Cached News: