HOME >> BIOLOGY >> NEWS
Brain networks strengthened by closing ion channels

New Haven, Conn. -- Yale School of Medicine and University of Crete School of Medicine researchers report in Cell April 20 the first evidence of a molecular mechanism that dynamically alters the strength of higher brain network connections.

This discovery may help the development of drug therapies for the cognitive deficits of normal aging, and for cognitive changes in schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder (ADHD).

"Our data reveal how the brains arousal systems influence the cognitive networks that subserve working memorywhich plays a key role in abstract thinking, planning, and organizing, as well as suppressing attention to distracting stimuli," said Amy Arnsten, lead author and neurobiology professor at Yale.

The brains prefrontal cortex (PFC) normally is responsible for so-called executive functions. The ability of the PFC to maintain such memory-based functions declines with normal aging, is weakened in people with ADHD, and is severely disrupted in disorders such as schizophrenia and bipolar disorder.

The current study found that brain cells in PFC contain ion channels called hyperpolarization-activated cyclic nucleotide-gated channels (HCN), that reside on dendritic spines, the tiny protrusions on neurons that are specialized for receiving information. These channels can open when they are exposed to cAMP (cyclic adenosine monophosphate). When open, the information can no longer flow into the cell, and thus the network is effectively disconnected. Arnsten said inhibiting cAMP closes the channels and allows the network to reconnect.

The study also found alpha-2A adrenergic receptors near the channels that inhibit the production of cAMP and allow the information to pass through into the cell, connecting the network. These receptors are stimulated by a natural brain chemical-norepinephrine-or by medications like guanfacine.

"Guanfacine can strengthen the connectivity of these networks by kee
'"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Porter Novelli
20-Apr-2007


Page: 1 2

Related biology news :

1. Brain blood flow gives clues to treating depression
2. Brains hearing center may reorganize after implant of cochlear device
3. Brains inertial navigation system pinpointed
4. Brain, size and gender surprises in latest fossil tying humans, apes and monkeys
5. Brains reflect sex differences
6. Brain tumors coax important support from nearby immune system cells
7. Brain tissue reveals possible genetic trigger for schizophrenia
8. Brain fends off distractions
9. Brain works more chaotically than previously thought
10. Brain maps online
11. Brains reward circuit activity ebbs and flows with a womans hormonal cycle

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/3/2019)... ... October 02, 2019 , ... Personalized Stem Cells, ... patient in an FDA approved clinical trial for stem cell treatment of knee ... formation of the company as a subsidiary of VetStem Biopharma. , PSC CEO, Michael ...
(Date:9/30/2019)... ... September 30, 2019 , ... ... mesenchymal stem/stromal cell (hMSC) biomanufacturing systems, today announced it has received patent ... product formats (patent number AU 2015259373). This new patent adds intellectual property ...
(Date:9/25/2019)... ... , ... Deep Science Ventures (DSV), a new paradigm for applied ... of cancer research. , Deep Science Ventures was founded to create a better method ... from the start, both at the industry and biological level. , Through their ...
Breaking Biology News(10 mins):
(Date:9/30/2019)... (PRWEB) , ... September 30, 2019 , ... ... materials science newsletter from Rigaku Corporation , is now available online on ... to X-ray based materials science, including X-ray diffraction, fluorescence and imaging, and presents ...
(Date:9/24/2019)... (PRWEB) , ... September 24, ... ... provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... a clinical-stage biopharmaceutical company focused on the development of therapies to treat ...
(Date:9/24/2019)... ... , ... In the past three years, the National Science Foundation (NSF) has ... School of Mines & Technology that expands human understanding of the microbial world. ... slimy and yet strong layer which is commonly known as a biofilm. , The ...
(Date:9/17/2019)... ... 2019 , ... Tucker, a Labrador retriever, was just a puppy when he ... and lame on his right hip and elbow. At one year of age, Tucker ... case the vet had seen.” He was prescribed pain medications, both oral and injectable, ...
Breaking Biology Technology:
Cached News: