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Brain plays key role in diabetes therapy

insulin response before injecting the animals with the hormone. Without the normal brain response to insulin, the hormone therapy's efficacy for reducing blood sugar fell by about 35%, Schwartz said. Furthermore, they found that gene therapy interventions designed to increase the brain's insulin response heightened the animals' response to therapy about 2-fold.

Strategies that target the molecules involved in the brain's response to insulin "may therefore prove beneficial in the management of diabetes in humans," the researchers said.

Differences in brain sensitivity to the insulin hormone might also help to explain the often "huge variation in insulin requirement" among otherwise comparable diabetes patients, Schwartz said.


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Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
10-Jan-2006


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