HOME >> BIOLOGY >> NEWS
Brain's cannabinoid system 'mellows' seizures

ced seizures increased in the mice. In fact, their experiments all but ruled out the role of GABAergic neurons in the seizure-protection function, they concluded.

"Altogether, these results confirm that physiological endocannabinoid-dependent control of GABAergic transmission depends on intact CB1 signaling in GABAergic interneurons and suggest that the endocannabinoid system does not influence GABAergic transmission during the development of KA-induced seizures," they concluded. "Therefore, direct modulation of glutamatergic transmission by CB1 receptors expressed on cortical glutamatergic neurons appears to be the major mechanism of endocannabinoid-mediated protection against KA-induced seizures."

Furthermore, the researchers' experiments established that endocannabinoid receptors were also present in the same glutamatergic neurons in areas of the hippocampus known to be central to seizure generation. The researchers wrote that this finding "represents a novel step in understanding the progression of acute excitotoxic seizures and the development of epileptic states."

And significantly, when the researchers used a targeted virus to knock out the CB1 gene for the endocannabinoid receptor specifically in the glutamatergic neurons of the hippocampus, the mice also showed strong worsening of chemically induced seizures in comparison to mice still expressing CB1.

"Altogether, these observations support a hypothetical scenario in which acute KA-induced excitotoxic seizures would activate the endocannabinoid system in respect to its ability to inhibit only 'harmful' glutamatergic transmission, but not 'protective' GABAergic release," concluded Lutz, Marsicano, and colleagues.

"In conclusion, our study reveals a mechanism through which the endocannabinoid system is able to provide on-demand protection against acute behavioral seizures. CB1 expression on hippocampal glutamatergic circuits accounts for this protection and mi
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
16-Aug-2006


Page: 1 2 3

Related biology news :

1. Brains hearing center may reorganize after implant of cochlear device
2. Brains inertial navigation system pinpointed
3. Brains reward circuit activity ebbs and flows with a womans hormonal cycle
4. Brains fear center likely shrinks in autisms most severely socially impaired
5. Brains receptors sensitive to pot may open door in treating drug dependence, brain disorders
6. Brains own cannabis compound protects against inflammation
7. Brains opioid receptorsor endorphin systemmay hold key to treatment possibilities for bulimia
8. Endogenous cannabinoids linked to fetal brain damage imposed by maternal cannabis use
9. Endocannabinoids the brains cannabis demonstrate novel modes of action to stress
10. Bursts of waves drive immune system soldiers toward invaders
11. New system of wastewater treatment could reduce the size of treatment plants by half

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology to ... display is the latest premium product recently added to the range of products distributed ... ... ... Imaging- LCD Medical Display- Ampronix News ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... ... NeuMedics Inc. is pleased to announce that CEO Iain Duncan has been invited ... The session begins at 1:10 PM and Iain will present the proof of concept ... topical agent and a treatment for ophthalmic complications of diabetes. , Mr. Duncan will ...
(Date:5/27/2016)... ... 27, 2016 , ... Weeks after hosting a carpal tunnel syndrome workshop with ... surgeon and founder of the Fitzmaurice Hand Institute, has announced the addition of MRI ... state-of-the-art technology and only 1 of about 3 currently available in the United States. ...
(Date:5/27/2016)... ... , ... PBI-Gordon Corporation is pleased to announce Dave Loecke has accepted the ... with PBI-Gordon, Dave has served in a wide variety of roles. His most recent ... launch of many of PBI-Gordon’s most successful products. , “Dave has been essential to ...
(Date:5/27/2016)... ... May 27, 2016 , ... Doctors in Italy, Japan, the UK and ... BRCA-1 associated protein (BAP1) gene and its link to malignant mesothelioma. Surviving Mesothelioma has ... read the full article now. , The studies analyzed for the new report ...
Breaking Biology Technology:
Cached News: