HOME >> BIOLOGY >> NEWS
Brainstem blocks pain to protect key behaviors

erstand the neural basis of this form of pain suppression, the researchers next inserted electrodes to monitor brain activity in feeding rats.

The suspected source of pain relief was a cluster of cells in the VMM. In 1979, Howard Fields of the University of California at San Francisco identified two groups of neurons in the brain stem that could enhance or inhibit pain. Neurons that "facilitate" pain, which he labeled "ON cells, fire in bursts when animals are awake and are inactive during slow-wave sleep. "OFF" cells, which suppress pain, are active during slow-wave sleep.

Foo and Mason, who completed her post-doctoral training in Fields' laboratory, found that the pain-enhancing ON cells were inhibited and the pain-suppressing OFF cells were excited during feeding, results that duplicated the effects of morphine. The changes occurred only during selected portions of eating, while the animal was both holding and chewing the food. A similar response took place when the animals drank water or urinated.

This response "protects critical behaviors from disruption," the authors note, "allowing an animal to nourish itself without being distracted." (Animals that don't urinate are at high-risk for infections.)

As a final test the authors used drugs to inactivate the VMM. This completely eliminated the delayed response to pain.

"This is the best evidence so far on the biological significance of OFF cell activity," said UCSF's Fields, who was not connected with the study. "It is a major step in understanding the neurobiological mechanisms of decision making in the face of conflict -- in this case the choice between whether to feed or flee. Off cells help you feed instead of flee."

Mason and Foo also found, however, that in situations that might be more dangerous, the feed-or-flee balance could be tipped the other way. Given just before feeding, a strong puff of air perhaps indicating a nearby predator -- activated
'"/>

Contact: John Easton
john.easton@uchospitals.edu
773-702-6241
University of Chicago Medical Center
7-Nov-2005


Page: 1 2 3

Related biology news :

1. Molecule blocks gene, sheds light on liver cancer
2. MIT researchers probe bones tiny building blocks
3. Blood sugars manufacture limited by building blocks supply
4. Drug blocks lethal motor-neuron disease in mice
5. Yale chemists show that nature could have used different protein building blocks
6. Sentry enzyme blocks two paths to Parkinsons disease
7. Researchers discover surprising drug that blocks malaria
8. New drug blocks influenza, including bird flu virus
9. Cigarette smoke blocks cell repair mechanism, University of Florida study shows
10. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
11. Patent awarded for LSUHSC-developed peptide that blocks lethal toxins of anthrax

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brainstem blocks pain protect key behaviors

(Date:7/13/2015)... SAN JOSE, Calif. , July 13, 2015 ... the leading developer of human interface solutions, today ... second generation touch and display driver integration (TDDI) ... solution is the first to combine Synaptics , ... expertise with proven display driver technology developed in ...
(Date:7/9/2015)... 2015 Research and ... the "Biometrics for Banking; Market & Technology ... to their offering. The adoption for ... growth and the forecast is that by 2020 ... companies involved in delivering biometric systems to the ...
(Date:7/8/2015)... 2015 Summary Pancreatic cancer is the ... fatal, with a mortality rate of 10.9 deaths per ... cancer patients has highlighted a significant need for new ... met by the current market. A highly active ... varying molecule types and mechanisms of action, which provides ...
Breaking Biology News(10 mins):Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3
(Date:7/29/2015)... July 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... Company,s Chief Financial Officer has resigned.  The Company has ... Officer who retired in December 2014, as full time ... permanent successor.     Andy Ashworth began ... ensure a smooth transition.  Andy was the Company,s CFO ...
(Date:7/29/2015)... 2015 Research and ... of the "Global Biosimilars Market, 2015 - ... The Global Biosimilars Market, 2015 - 2025, report ... biosimilars market. With the blockbuster biologics losing patent ... biosimilars are being viewed as viable substitutes to ...
(Date:7/29/2015)... July 29, 2015  Pfenex Inc. (NYSE MKT: PFNX) ... will be released on Thursday, August 13, 2015, before ... Pfenex management will host a conference call to discuss ... press release outlining the financial results and business update ... Please call 1-866-376-8058 (US) or 1-412-542-4131 (international) and ...
(Date:7/29/2015)... 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: AEZS ... an optimized Erk inhibitor molecule for development, thus ... a new class of potential cancer therapies. ... target for therapeutic intervention in cancer. Recently approved ... for B-Raf and Mek inhibitors. Erk inhibitors may ...
Breaking Biology Technology:BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3
Cached News: