HOME >> BIOLOGY >> NEWS
Breakthrough in understanding type 2 diabetes as key genes identified

The most important genes associated with a risk of developing type-2 diabetes have been identified, scientists report today in a new study.

The research, published online in Nature, is the first time the genetic makeup of any disease has been mapped in such detail. It should enable scientists to develop a genetic test to show an individual their likelihood of developing diabetes mellitus type 2, commonly known as type-2 diabetes.

The researchers identified four loci, or points on individuals' genetic maps, which corresponded to a risk of developing the disorder. The scientists, from Imperial College London, McGill University, Canada, and other international institutions, believe their findings explain up to 70% of the genetic background of type-2 diabetes.

In addition, one of the genetic mutations which they detected might further explain the causes behind type-2 diabetes, potentially leading to new treatments. The research revealed that people with type-2 diabetes have a mutation in a particular zinc transporter known as SLC30A8, which is involved in regulating insulin secretion. Type-2 diabetes is associated with a deficiency in insulin and the researchers believe it may be possible to treat it by fixing this transporter.

Professor Philippe Froguel, one of the authors of the study from the Division of Medicine at Imperial College London, said: "The two major reasons why people develop type-2 diabetes are obesity and a family link. Our new findings mean that we can create a good genetic test to predict people's risk of developing this type of diabetes.

"If we can tell someone that their genetics mean they are pre-disposed towards type-2 diabetes, they will be much more motivated to change things such as their diet to reduce their chances of developing the disorder. We can also use what we know about the specific genetic mutations associated with type-2 diabetes to develop better treatments."

The sc
'"/>

Contact: Laura Gallagher
L.Gallagher@imperial.ac.uk
44-020-759-46702
Imperial College London
14-Feb-2007


Page: 1 2

Related biology news :

1. Breakthrough developments in rheumatoid arthritis reported
2. Breakthrough for treatment of fatal heart condition
3. Breakthrough vaccine to treat chemo-resistant ovarian cancer
4. Breakthrough in nanodevice synthesis revolutionizes biological sensors
5. Breakthrough for future exploration unrecoverable gas reserves
6. Breakthrough by MUHC researcher has major implications
7. Breakthrough offers new tool for studying degenerative disease
8. Breakthrough in brain injury study at University of Leicester
9. Breakthrough for stem cell research
10. Sciences Breakthrough of the Year: Watching evolution in action
11. Breakthrough technology from Pall increases platelet availability and safety

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... to grow at a CAGR of 30.37% during the period 2017-2021. ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
Breaking Biology News(10 mins):
(Date:5/24/2017)... ... May 24, 2017 , ... Benchworks ... the Mid-Atlantic chapter of the Healthcare Businesswomen’s Association (HBA). Nominated by ... Mid-Atlantic chapter board meets in person once each quarter and holds monthly conference ...
(Date:5/24/2017)... BOSTON , May 23, 2017 As Ebola ... with four deaths and 20 suspected cases now reported, ... via the PubMed database, showed a correlation between the 2014 ... gene Replikin counts rose sharply in 2012-13, which preceded the ... rise in the Ebola gene Replikin counts in 2014-15, which ...
(Date:5/23/2017)... ... 2017 , ... NetDimensions has been ranked as a Leader ... Corporate Learning, 2017. , Aragon Research defines Leaders as organizations who possess comprehensive ... those strategies. NetDimensions’ ranking as a Leader due to its strengths in: , ...
(Date:5/23/2017)... ... May 23, 2017 , ... Bacterial biofilms, surface adherent communities ... cause diverse pathologies ranging from food poisoning and catheter infections to gum disease and ... the tens of billions of dollars per year, there is currently a paucity of ...
Breaking Biology Technology:
Cached News: