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Breast cancer genetics and more -- press release from PLoS Medicine

that accounts for 40% of inherited breast cancer risk in Iceland.

These results suggest that inheriting the BARD1 Cys557Ser allele increases a woman's breast cancer risk, but for most women the risk is only slight. However, the increase in risk for women who also carry the BRCA2 999del5 mutation is dramatic, and in that context it may be worthwhile developing a clinical test for the BARD1 Cys557Ser allele. These findings need to be confirmed in other groups of patients before anyone is routinely tested for the BARD1 variant.

Citation: Stacey SN, Sulem P, Johannsson OT, Helgason A, Gudmundsson J, et al. (2006) The BARD1 Cys557Ser variant and breast cancer risk in Iceland. PLoS Med 3(7): e217.

PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030217

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-07-stacey.pdf

Related images for press use: http://www.plos.org/press/plme-03-07-stacey.jpg

Caption: Geographical Ancestry of BARD1 Cys557Ser Carriers in Iceland

CONTACT:
Edward Farmer
Director of Corporate Communication
deCODE Genetics
+1 646 417 4555
edward.farmer@decode.is

THE FOLLOWING RESEARCH ARTICLES WILL ALSO BE PUBLISHED ONLINE:

Embryonic Pig Pancreatic Tissue Transplantation for the Treatment of Diabetes

Pancreatic tissue from embryonic pigs co-transplanted with or without human immune cells into immune-deficient mice suggests that the embryonic stage of the pig donor affects the immunogenicity of the graft.

Citation: Eventov-Friedman S, Tchorsh D, Katchman H, Shezen E, Aronovich A, et al. (2006) Embryonic pig
'"/>

Contact: Andrew Hyde
ahyde@plos.org
44-122-346-3330
Public Library of Science
19-Jun-2006


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