HOME >> BIOLOGY >> NEWS
Breast stem cells have features similar to 'basal' tumors

The most aggressive form of breast cancer may originate from breast stem cells that have undergone genetic mishaps.

Victorian Breast Cancer Research Consortium scientists from The Walter and Eliza Hall Institute, using mouse models, have discovered that breast stem cells do not express receptors for the female hormones oestrogen or progesterone. These and other features of the stem cell resemble the aggressive 'basal' subtype of breast cancer. There is increasing evidence that breast cancer is not simply a single disease. Scientists now view breast cancer as a heterogeneous disease, made up of various subtypes. This observation has led to speculation that breast tumours are derived from different cell types that could include the breast stem cell or its descendents that have suffered genetic accidents.

This possibility has generated great interest in understanding the composition of normal breast cells including the stem cell. A question of particular interest is whether the breast stem cell expresses receptors for oestrogen and progesterone and the marker 'Her2', since these help define the subtypes of breast cancer; and also guide current approaches to therapy.

The WEHI team, together with the Eaves group in Vancouver, have found that the breast stem cell in mice is 'triple negative' for oestrogen, progesterone and Her2 receptors but does express certain 'basal cell' markers. These characteristics also define the basal subtype of breast cancer, which is more commonly seen in tumours that develop in women who are carriers of the breast cancer predisposing gene BRCA1.

These findings support previous speculation that breast stem cells, or very early descendents, are the cells from which basal tumours arise. Dr Visvader, who led the team effort with Dr Lindeman at WEHI, said, "This finding made by Marie-Liesse Asselin-Labat in our lab reinforces the need to understand the normal biology of the breast stem cell. Our hope is
'"/>

Contact: Brad Allen
61-40-303-6116
Research Australia
19-Jul-2006


Page: 1 2

Related biology news :

1. Breast cancer and hormone therapy -- A looking-glass mirror?
2. Breast cancer prognosis runs in the family
3. Breast cancer milieu -- Progression, tamoxifen sensitivity, and DNA reversion
4. Is bigger better? Breast surgery linked to boost in self-esteem and sexuality
5. Breast cancer treatment heats up
6. Genesearch Breast Lymph Node assay detects breast cancer metastases with greater sensitivity
7. Breast Cancer Month story tips from Georgetown University Medical Center
8. Breast density helps predict breast cancer risk
9. Breast cancer genetics and more -- press release from PLoS Medicine
10. Breast-sparing surgery an option for women with breast cancer gene mutation, U-M-led study finds
11. Breast implants not associated with cancer risk, study reports

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 24, 2020 , ... Elgia ... inflammatory and fibrotic diseases, today announced that Dr. Stacie Canan has joined the ... Dr. Canan previously served as Executive Director of Global Health at Bristol Myers ...
(Date:8/23/2020)... (PRWEB) , ... August 21, 2020 , ... ... Rigaku Corporation has been published and is now available on the company’s ... X-ray diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. ...
(Date:8/21/2020)... (PRWEB) , ... August 20, 2020 , ... ... that Hassan Movahhed , a Clinical Operations executive with expertise in clinical ... has joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed ...
Breaking Biology News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... Slone ... companies, has announced the placement of Julianne Averill , CPA, as Chief ... all financial operations and implementing key business strategies to accelerate Alveo’s growth as ...
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the leading platform ... Advisory Board (SAB) to research the medical potential of terpenes and the potential ... with terpenes. The board is focused on expanding the recently launched line of effects-based ...
(Date:8/12/2020)... Mass. (PRWEB) , ... August 11, 2020 , ... ... $300,000 a year to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial Research ... in 2021 and 2022. The network is a consortium of academic research centers ...
(Date:8/12/2020)... Mich. (PRWEB) , ... August 12, 2020 , ... ... Group, Inc. (EMMA International), a global leader in FDA compliance consulting has ... the nation’s fastest-growing private companies. The list represents a unique look at the ...
Breaking Biology Technology:
Cached News: