A team led by Dr Dave Bates, British Heart Foundation Lecturer, and Dr Steve Harper, Senior Research Fellow in the Microvascular Research Laboratories, in the Department of Physiology at Bristol University, have discovered that a type of vascular endothelial growth factor (VEGF) found in normal tissue, including blood, can prevent cancers from growing. The research findings will be published in the world's most prestigious scientific cancer journal, 'Cancer Research', next week [1 November 2004].
The growth of any cancer depends on its ability to maintain a blood supply that will deliver nutrients. For a cancer to grow from the size of a pinhead to that of a golf-ball, the blood supply of the tumour has to grow with the expansion of the tumour itself. Most forms of VEGF help this blood vessel growth. The new form of VEGF, VEGF165b, which was discovered by the same team in 2002, inhibits the growth of new blood vessels required for tumours to grow above one millimetre.
They have also found that this form of VEGF is generally found in many normal parts of the body, including the prostate, but not in prostate cancer, and have established how this form of VEGF works on blood vessels.
The identification of how this new form of VEGF works, and its effects on tumours, means that it could be possible to prevent tumour growth by starving the tumour using the body's own anti-cancer agent, VEGF165b. The advantage of using VEGF165b over established compounds to treat cancer is that VEGF165b is a natural protein produced by the body under normal circumstances. Many new cancer therapies are based on starving the tumour of nutrients by attacking the tumour blood supply rather than the cancer cells. Blocking VEGF using antibodies has recently been shown to be effective in large-scale trials in colorectal cancer in the United States.
Contact: Joanne Fryer
University of Bristol