Broad Institute scientists awarded $18M CARE grant

The Broad Institute of MIT and Harvard announced today an award from the National Heart, Lung, and Blood Institute (NHLBI) for more than $18M to support genomic studies aimed at unveiling the genetic variations that underlie common human diseases. These funds will help to build a common data resource for the entire biomedical community that systematically combines genetic analyses of heart, lung, blood, and sleep disorders with detailed information about disease characteristics in a range of patient groups.

"The research funded by this award should result in new insights into how genetic variation contributes to health and disease," said Stacey Gabriel, principal investigator of the grant and the director of the Genetic Analysis platform and the National Center for Genotyping and Analysis at the Broad Institute. "We will work together with other members of the CARE network to combine new methods for measuring genetic variation with an unprecedented collection of large, well-characterized clinical cohorts."

Known as the candidate gene association resource, or CARE, this project will survey the DNA of 50,000 individuals, using large-scale genotyping technologies and advanced informatics, to highlight the differences contained in specific genes of interest. These "candidate" genes represent a prioritized list of the likely sources of inherited variation that are most relevant for human disease.

"The sheer scale of this project with genetic data collected from as many as 50,000 participants allows for more in-depth analyses of diseases across multiple races and ethnicities," said NHLBI Director Elizabeth G. Nabel, M.D. "The database will be a tremendous resource for scientists -- speeding identification of risk factors and genetic variants associated with disease and disorders."

While inherited differences within our genes likely play roles in common diseases that affect major organ systems, such as the heart, lung and blood, their con

Contact: Nicole Davis, Broad Institute of MIT and Harvard
Broad Institute of MIT and Harvard

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