HOME >> BIOLOGY >> NEWS
Brown cancer biologists identify major player in cell growth

PROVIDENCE, R.I. [Brown University] -- When cells go about the business of dividing, they can get sidelined. Maybe there aren't enough nutrients. Maybe there aren't the right signals to resume multiplying. Either way, cells go quiet.

What can restart cell division -- the process that drives the development of embryos, the renewal of hair, skin and blood, and the creation of cancer -- is a single transcription factor called GABP, according to new research from The Warren Alpert Medical School of Brown University and Rhode Island Hospital.

The work, published online in Nature Cell Biology, introduces a new pathway that can be manipulated to control cell growth. Since cell growth is a fundamental biological process, the research may shed light on everything from miscarriages to muscular dystrophy. The main application, however, is cancer. Since a key characteristic of cancer cells is unchecked growth, the research identifies potential targets for new treatments.

"As a scientist and a physician, I am tremendously excited," said Alan Rosmarin, M.D., an associate professor in the Department of Medicine and the Department of Molecular Biology, Cell Biology and Biochemistry at Brown and director of clinical oncology research for Lifespan, Rhode Island's largest health care system. "This discovery not only adds to our basic understanding of cell division, it could lead to better cancer drugs. And they're needed. Cancer touches everyone."

During the cell cycle, the four-phase process of cell division, there is a period when the biochemical brakes are put on and cells become inactive. Then the process is kick-started and cells move into the so-called S phase, when DNA is duplicated. This is a critical juncture. If genes are missing or broken, these alterations are passed on to the new cell -- and could result in disability or in diseases such as cancer.

So biologists are keenly interested in identifying the accelerators that
'"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
6-Feb-2007


Page: 1 2

Related biology news :

1. Brown rot shrivels prune production in California
2. Bones in motion: Brown scientists to create new 3-D X-ray system
3. Brown team finds crucial protein role in deadly prion spread
4. Genomic variation easier to identify with UCSD/Brown software
5. Brown scientists map structure of DNA-doctoring protein complex
6. Brown and OTS will jointly manage new ILTER network secretariat
7. Brownfields may turn green with help from Michigan State research
8. NIH grants $11 million to Brown University for cancer research
9. Prions rapidly remodel good protein into bad, Brown study shows
10. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
11. Brown wins major award to improve environment, protect RI health

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient MasterClass ... is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of savory ... at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting & ...
(Date:7/1/2020)... N.J. (PRWEB) , ... July 01, 2020 , ... ... announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in ... the company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot ...
(Date:6/25/2020)... MANSFIELD, Mass. (PRWEB) , ... June 24, 2020 ... ... provider of cloud-based enterprise software and software-driven clinical data services that accelerate drug ... trials for low-dose selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands ... , Known as MediVet Biologics since its formation in 2016, the company is ... Animal Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... have entered into a strategic partnership whereby Catalent will provide support for the ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter ... great surgery is only the beginning of a successful study, while protecting and accessing ... Brad Gien, Global Head of Surgery from Envigo in a live ...
Breaking Biology Technology:
Cached News: