HOME >> BIOLOGY >> NEWS
Brown team finds crucial protein role in deadly prion spread

PROVIDENCE, R.I. [Brown University] -- A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

The findings are exciting, researchers say, because they might reveal a way to control the spread of prions through drug intervention. If a drug could be made that inhibits this fragmentation process, it could substantially slow the spread of prions, which cause mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans.

Because similar protein replication occurs in Alzheimer's and Parkinson's diseases, such a drug could also slow progression of these diseases as well.

"The protein fragmentation we studied has a big impact on how fast prion diseases spread and may also play a role in the accumulation of toxic proteins in neurodegenerative diseases like Parkinson's," said Tricia Serio, an assistant professor in Brown's Department of Molecular Biology, Cell Biology and Biochemistry and lead researcher on the project.

The findings from Serio and her team, which appear online in PLoS Biology, build on their groundbreaking work published in Nature in 2005. That research showed that prions strange, self-replicating proteins that cause fatal brain diseases convert healthy protein into abnormal protein through an ultrafast process.

This good-gone-bad conversion is one way that prions multiply and spread disease. But scientists believe that there is another crucial step in this propagation process fragmentation of existing prion complexes. Once converted, the thinking goes, clusters of "bad" or infectious protein are smashed into smaller bits, a process that creates "seeds" so that prions multiply more quickly in the body. Hsp104, a molecule known to be required for prion replication, could function as this protein "
'"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
23-Jan-2007


Page: 1 2

Related biology news :

1. Brown rot shrivels prune production in California
2. Brown cancer biologists identify major player in cell growth
3. Bones in motion: Brown scientists to create new 3-D X-ray system
4. Genomic variation easier to identify with UCSD/Brown software
5. Brown scientists map structure of DNA-doctoring protein complex
6. Brown and OTS will jointly manage new ILTER network secretariat
7. Brownfields may turn green with help from Michigan State research
8. NIH grants $11 million to Brown University for cancer research
9. Prions rapidly remodel good protein into bad, Brown study shows
10. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
11. Brown wins major award to improve environment, protect RI health

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/28/2020)... ... January 28, 2020 , ... ... improve care efficiency, reduce total cost of care, and limit the utilization of ... healthcare provider group headquartered in San Antonio, Texas specializes in improving care delivery ...
(Date:1/27/2020)... DIEGO (PRWEB) , ... January 27, 2020 , ... ... Thorne as Chairman. Thorne is a noted investor, tech entrepreneur, and former senior ... as Executive Chairman of Broadline Capital, the global alternative investment firm. , ...
(Date:1/24/2020)... (PRWEB) , ... January 24, 2020 , ... ... a partnership to mobilize Colorado’s capital resources to support early-stage bioscience companies in ... but early-stage startups have struggled to find the funding they need to innovate ...
Breaking Biology News(10 mins):
(Date:2/19/2020)... ... February 18, 2020 , ... Shoreline Biome, ... the strain level, recently unveiled a novel DNA isolation product. , Shoreline Rapid ... of high molecular weight (HMW) single-stranded DNA (ssDNA) in excess of 40 kB ...
(Date:2/11/2020)... BALTIMORE (PRWEB) , ... February 11, 2020 , ... ... biosolids and residuals solutions services in North America, today announced that the City ... long-term solution to its biosolids management needs. Commencing in April of 2020, Synagro ...
(Date:2/3/2020)... (PRWEB) , ... February 03, 2020 , ... ... offices in Cambridge, MA, announce that OmniType, the 11-locus, single tube multiplex successor ... OmniType is a best-in-class product featuring locus-multiplexing and short library preparation, for HLA ...
(Date:1/27/2020)... (PRWEB) , ... January 27, 2020 , ... ... announced it has secured financing from strategic investors led by Halma plc ... from existing investors Sonion, TDF Ventures, GII LLC, and WSJ Joshua Fund. A ...
Breaking Biology Technology:
Cached News: