HOME >> BIOLOGY >> NEWS
Brown team finds crucial protein role in deadly prion spread

PROVIDENCE, R.I. [Brown University] -- A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

The findings are exciting, researchers say, because they might reveal a way to control the spread of prions through drug intervention. If a drug could be made that inhibits this fragmentation process, it could substantially slow the spread of prions, which cause mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans.

Because similar protein replication occurs in Alzheimer's and Parkinson's diseases, such a drug could also slow progression of these diseases as well.

"The protein fragmentation we studied has a big impact on how fast prion diseases spread and may also play a role in the accumulation of toxic proteins in neurodegenerative diseases like Parkinson's," said Tricia Serio, an assistant professor in Brown's Department of Molecular Biology, Cell Biology and Biochemistry and lead researcher on the project.

The findings from Serio and her team, which appear online in PLoS Biology, build on their groundbreaking work published in Nature in 2005. That research showed that prions strange, self-replicating proteins that cause fatal brain diseases convert healthy protein into abnormal protein through an ultrafast process.

This good-gone-bad conversion is one way that prions multiply and spread disease. But scientists believe that there is another crucial step in this propagation process fragmentation of existing prion complexes. Once converted, the thinking goes, clusters of "bad" or infectious protein are smashed into smaller bits, a process that creates "seeds" so that prions multiply more quickly in the body. Hsp104, a molecule known to be required for prion replication, could function as this protein "
'"/>

Contact: Wendy Lawton
Wendy_Lawton@brown.edu
401-863-1862
Brown University
23-Jan-2007


Page: 1 2

Related biology news :

1. Brown rot shrivels prune production in California
2. Brown cancer biologists identify major player in cell growth
3. Bones in motion: Brown scientists to create new 3-D X-ray system
4. Genomic variation easier to identify with UCSD/Brown software
5. Brown scientists map structure of DNA-doctoring protein complex
6. Brown and OTS will jointly manage new ILTER network secretariat
7. Brownfields may turn green with help from Michigan State research
8. NIH grants $11 million to Brown University for cancer research
9. Prions rapidly remodel good protein into bad, Brown study shows
10. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
11. Brown wins major award to improve environment, protect RI health

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brown team finds crucial protein role deadly prion spread

(Date:10/28/2014)... juices are associated with a lower risk of developing ... of East Anglia (UEA). , Research published today ... flavanones (both subclasses of dietary flavonoids) significantly decrease their ... of cancer death among women. , The research ... between 25 and 55 for more than three decades. ...
(Date:10/27/2014)... German . ... via electrical signals, they communicate with each other at ... substances, the neurotransmitters, are stored in vesicles at the ... vesicles fuse with the cell membrane and release their ... synapses always have some readily releasable vesicles on standby. ...
(Date:10/27/2014)... breakthroughs may pave the way for vaccines and ... These flatworms, including tapeworms that cause hydatid diseases ... infect more than 300 million people and cause ... to chronic illness and death each year. , ... immunology, and tropical medicine, and scientific director of ...
Breaking Biology News(10 mins):Tea and citrus products could lower ovarian cancer risk, new UEA research finds 2Synapses always on the starting blocks 2Synapses always on the starting blocks 3GW researcher adapting breakthrough technologies to combat parasitic worm infections 2
(Date:10/27/2014)... The Italian company Roadrunnerfoot ... sell its artificial "lower limb", after the German ...      (Photo: http://photos.prnewswire.com/prnh/20141027/713097 ) , ... definitive judgement has arrived: Roadrunnerfoot, the small Italian ... hi-tech prostheses with composite materials, has won against ...
(Date:10/27/2014)... Kalorama Information says that PCR is demonstrating ... the United States and is the ... said the FDA,s Emergency Use Authorization (EUA) to authorize the ... detection of the Ebola virus was an indication that ... the IVD industry and its biennial survey on diagnostics ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 New ... SoundConnect , an industry leading unified communication ... partners and agents to deliver cloud-based audio and ... growth opportunities. , With SoundConnect’s Q4 incentive ... twenty-five video and/or web conferencing licenses sold, now ...
(Date:10/27/2014)... 27, 2014 The report “Smart ... Traffic Management, Communication, Monitoring), and by Display (Variable ... 2019” segments the global market into various sub-segments ... also identifies the drivers and restraints for this ... , Browse 75 market tables and 37 figures ...
Breaking Biology Technology:Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3SoundConnect Unveils Q4 Partner Incentives 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4
Cached News: