Burnham Institute awarded $13 M for Program of Excellence in Nanotechnology

solutions to combat vulnerable plaque; 1) building delivery vehicles that can be used to transport drugs and nanodevices to sites of vulnerable plaque; 2) designing a series of self-assembling polymers that can be used as molecular nano-stents to physically stabilize vulnerable plaque, 3) creating nano-machines comprised of human proteins linked to synthetic nano-devices for the purpose of sensing and responding to vulnerable plaque.

"The Programs of Excellence in Nanotechnology is a vitally important research effort that will spur the development of novel technologies to diagnose and treat heart, lung, and blood diseases," said Elizabeth G. Nabel, M.D., director of the National, Heart, Lung and Blood Institute of the NIH. "The program brings together bioengineers, materials scientists, biologists, and physicians who will work in interdisciplinary teams. By taking advantage of the unique properties of materials at the nanoscale, these teams will devise creative solutions to medical problems."

PEN Director, Jeffrey Smith, Ph.D., Professor, The Burnham Institute, will oversee the Program's administrative and training components, as well as his own research component. Dr. Smith also directs the Center on Proteolytic Pathways at The Burnham Institute, recently established as one of first centers funded by the National Institute of Health's Roadmap Initiative. Erkki Ruoslahti, M.D., Ph.D., Distinguished Scientist and former President/CEO of The Burnham Institute, using in vivo phage display technology discovered in his laboratory, will identify and develop targeting elements needed to target the delivery of nanodevices to vulnerable plaque. Dr. Ruoslahti is credited with the first successful targeted delivery of a nanomachine into live tissue, using similar strategies. Also from The Burnham Institute are William B. Stallcup, Ph.D., Professor, who will supervise the and Francesca Marassi, Ph.D., Assistant Professor, who will provide NMR expertise for struc

Contact: Nancy Beddingfield
Burnham Institute

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