HOME >> BIOLOGY >> NEWS
Bursts of waves drive immune system 'soldiers' toward invaders

Scientists have discovered that torrents of microscopic waves propel white blood cells toward invading microbes. The discovery - recorded on videotape -- holds the potential for better understanding and treatment of cancer and heart disease.

Visible only under a very high-resolution light microscope, the dynamic waves are made of a signaling protein that directs cell movement. This protein and a second key player were already known to trigger cells to move, but their interaction to generate the self-sustaining waves has now been revealed.

"Seeing the wavelike dynamics of this protein, Hem-1, for the first time was easily the most instantly thrilling and illuminating finding in my scientific career," says Orion Weiner, PhD, of the University of California, San Francisco, who led the scientific team. "It immediately suggested how this protein might be organizing cell movement - an idea that our subsequent experiments validated.

"We never expected to see this sort of complex behavior within cells, but in retrospect it is an absolutely ingenious way to organize cell movement. We're getting our first glimpses that take us beyond knowing that this protein is important for cell motility to learning how it might organize the complex choreography of cell movement."

The videotape of the unsuspected action shows wave upon wave advancing like a series of exploding fireworks. The novel behavior can be viewed at cvri.ucsf.edu/~weiner.

The research findings are reported in the August 13, 2007 online edition of the journal "Public Library of Science (PLoS) Biology." Lead author is Weiner, who is assistant professor of biochemistry at UCSF.

Because the same kind of components scrutinized in the new research also drive cancer cell metastasis, the finding may lead to strategies to block cancer growth. Similarly, faulty regulation of white blood cell movement plays a role in heart attack - another promising target
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
13-Aug-2007


Page: 1 2 3 4

Related biology news :

1. Magnetic field uses sound waves to ignite suns ring of fire
2. Study: Living coral reefs provide better protection from tsunami waves
3. Slow brain waves play key role in coordinating complex activity
4. Toxic waves
5. NJIT chemists modify carbon nanotubes using microwaves
6. Evolution is driven by gene regulation
7. Spouse may drive you to drink but also can protect you from alcohol
8. Can a taste for poison drive speciation?
9. A genetic gang of 4 drives spread of breast cancer
10. Switching genes to overdrive improves muscular dystrophy symptoms in mice
11. Universities in 1.5M drive to cut cost of solar power

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2019)... (PRWEB) , ... March 21, 2019 , ... ... growth in recent years with a particular focus on machine learning. Machine learning ... data through a process called ‘learning’ or ‘training’. Through machine learning, scientists are ...
(Date:3/18/2019)... and BERKELEY, Calif. (PRWEB) , ... March 18, ... ... Pivot Bio, the leader in microbial solutions announce today they have ... Pivot Bio PROVENTM, Pivot Bio’s breakthrough product for biologic nitrogen fixation for corn. ...
(Date:3/13/2019)... VIEW, Calif. (PRWEB) , ... March 13, 2019 , ... ... up to 45 percent of the world’s population. One billion people ... breathing is interrupted during sleep - more than 80 percent of whom go undiagnosed. ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... LAWRENCEVILLE, N.J. (PRWEB) , ... ... ... announced the launch of a preclinical gold standard solution for preclinical research ... Execution System (LES) with end-to-end workflows, connected systems and facilities, innovative technology-driven ...
(Date:3/12/2019)... ... March 12, 2019 , ... ... research, has launched its third generation long-fragment DNA shearing innovation, the Megaruptor 3. ... a user-friendly interface, automated processing, and the ability to process up to ...
(Date:3/11/2019)... ... March 11, 2019 , ... USDM Life Sciences and Generis ... with built in GxP compliance for the life sciences industry. USDM Cloud Assurance ... continuous compliance for Generis’ flagship product, CARA. , Presentation One:, ...
(Date:3/9/2019)... ... March 08, 2019 , ... ... and higher education planning, announced the release of their Best Online Master's ... the nation based on curriculum quality, program flexibility, affordability, and graduate outcomes. ...
Breaking Biology Technology:
Cached News: