HOME >> BIOLOGY >> NEWS
CSH Protocols publishes cutting-edge methods for analyzing complex molecular interactions

Cold Spring Harbor, N.Y., Tues., Oct. 3, 2006 -- With the genomes of hundreds of organisms now catalogued, one of the next major challenges is to identify proteins and their interactions. The current issue of CSH Protocols, published online (www.cshprotocols.org), features two freely available, cutting-edge methods that address this challenge.

Elucidation of protein-DNA interactions has been a tedious process, limited to one protein-interaction partner at a time. But the advent of high-throughput, genomics-based technologies has enabled scientists to build large-scale maps of protein-DNA and protein-protein interactions. These methods--released in CSH Protocols--will be useful to researchers seeking to map these interactions and better understand fundamental biological processes.

One of the freely accessible protocols, developed by Dr. Marian Walhout and her colleagues at the University of Massachusetts Medical School, describes a means for identifying protein-DNA interactions in complex organisms. Her team has used this method to generate a protein-DNA interaction network by characterizing the DNA sequences to which proteins bind in the model organism C. elegans (the "worm" used in many developmental studies). Because it relies on basic molecular biology techniques, this method will also be useful for analyzing the intricately coordinated patterns of gene regulation in other species.

Another technical challenge facing researchers is that in a typical cell, proteins are present in relatively small quantities. The second free method in this release of CSH Protocols is "MuDPIT" (for Multidimensional Protein Identification Technology), a means of identifying rare proteins in complex mixtures. This method combines advanced protein identification technologies with computational analysis, and has already been successfully employed in characterizing interacting pro
'"/>

Contact: Michael Ronemus
ronemus@cshl.edu
516-422-4157
Cold Spring Harbor Laboratory
3-Oct-2006


Page: 1 2

Related biology news :

1. Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
2. Bioinformatics-related methods are featured in Cold Spring Harbor Protocols
3. Cold Spring Harbor Protocols features methods to understand embryos, clones, stem cells
4. Cold Spring Harbor Protocols highlights reliable methods for gene and protein analyses
5. A frenzy of fruit fly methods featured in Cold Spring Harbor Protocols
6. Lighting up life: Cold Spring Harbor Protocols presents tips for creating glowing plants
7. Cold Spring Harbor Protocols features methods for analyzing protein interactions
8. RNA interference methods highlighted in Cold Spring Harbor Protocols
9. Cold Spring Harbor Laboratory Press launches CSH Protocols
10. Cold Spring Harbor Laboratory Press to launch CSH Protocols
11. CMU researcher publishes anole lizard findings

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2020)... ... February 13, 2020 , ... Worldwide Business ... Nobio CEO Yoram Ashery to discuss how their revolutionary technology can kill ... bacteria to keep people healthy with their revolutionary nanoparticle technology. Nobio is on ...
(Date:2/11/2020)... ... February 11, 2020 , ... ... The LaunchPort™ medical device accelerator in Port Covington, Baltimore. The newly formed company ... must be addressed to manage increased demand for home dialysis treatments. The start-up ...
(Date:2/6/2020)... NEW YORK (PRWEB) , ... ... ... global, full-service clinical research organization (CRO) specializing in complex interventional medical device ... as Vice President, Regulatory Strategy. In this newly established role, Dorothy oversees ...
Breaking Biology News(10 mins):
(Date:1/28/2020)... ... January 28, 2020 , ... Today, Salimetrics announced ... The new Salivary Total Human IgG Assay Kit exemplifies Salimetrics’ 20+ ... saliva, researchers can extend the accuracy and ease of use of salivary bioscience ...
(Date:1/24/2020)... SOUTH RIDING, Va. (PRWEB) , ... January 24, ... ... analytics, and other innovations created by companies in biotechnology, diagnostics, therapeutics, laboratory and ... the lives of millions of people around the world. And as Slone ...
(Date:1/22/2020)... ... January 21, 2020 , ... Microbial Discovery Group LLC (MDG) ... Industrial and Institutional (I&I) Account Manager. Darrell will focus on servicing MDG’s partners ... over 30 years of sales experience working across multiple different market sectors such ...
(Date:1/10/2020)... ... January 09, 2020 , ... Phlexglobal, the leading provider ... of Cunesoft, a move that expands the company’s portfolio of best-of-breed technologies designed ... , Based in Munich, Germany, Cunesoft provides intelligent software and expert services for ...
Breaking Biology Technology:
Cached News: