HOME >> BIOLOGY >> NEWS
CSHL links activity in brain synapses and developmental abnormalities with schizophrenia gene

Cold Spring Harbor, NY Cold Spring Harbor Laboratory (CSHL) researchers have identified a function of neuregulin1 (NRG1), a gene previously linked to schizophrenia but whose role in the disease was unknown. "We found that when this gene or this pathway is impaired," explained CSHL's Bo Li. "It starts a chain reaction negatively impacting synapses in the brain which contribute to the abnormal development of brain circuits and may lead to schizophrenia."

By discovering the connections between genes and how they impact synapses and circuits in the brain, research is guiding the development of new strategies to diagnose and treat neurological disease. Published on May 24, 2007 in the journal Neuron, this latest research supports the hypothesis that schizophrenia is a disease that results from multiple factors, including genetic defects and developmental abnormalities in the brain. A lynchpin in the development of the disease is the brain's neurotransmitter system known as the glutamate system. When the glutamate system is suppressed it leads to abnormal brain development and schizophrenic symptoms.

Unlocking the mystery of NRG1 and its critical function in the normal development of the glutamate system was the result of a unique combination of technologies at CSHL. Under the direction of CSHL's Neuroscience Research Program Chair, Robert Malinow, M.D., Ph.D., researchers inform their study of diseased brains by the ongoing study of normal brains. "The ability to finally identify the functionality of NRG1 was possible here because of access to powerful technology that combined the ability to manipulate individual genes, to study the very structure of the glutamate synapse with a two-photon microscope, and to perform functional studies using electrophysiology."

Li hopes that his research will stimulate more exploration of the functions of NRG1 in the brain. "This gene and its pathway also have implications for other neurol
'"/>

Contact: Dagnia Zeidlickis
zeidlick@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
24-May-2007


Page: 1 2

Related biology news :

1. New textbook illuminates the close links between evolutionary and molecular biology
2. Preclinical study links gene to brain aneurysm formation
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. New mechanism links smoking to lung damage
5. UCLA study links air pollution to clogged arteries
6. University of Leeds strengthens China links in membrane and neurobiology
7. Satellite survey links tropical park fires with poverty and corruption
8. Genetic defect links respiratory disease and congenital heart disease
9. West African Ocean sediment core links monsoons to global climate evolution
10. Salk researchers discover first gene that specifically links calorie restriction to longevity
11. A new study links a stomach microbe to asthma prevention

Post Your Comments:
(Date:1/22/2015)... Jan. 15, 2015  BellBrook Labs, a leader in ... the launch of a TR-FRET (time resolved Forster ... UDP Assay, a high throughput screening assay for ... will allow for sensitive detection of hundreds of ...
(Date:1/22/2015)... Jan. 21, 2015  Analyst Report Issued by Small Cap IR. ... showed that planet-wide, transactions at merchants on the leading payment ... number of credit, debit, and prepaid cards reached 6.54 billion.  ... of fraudulent card usage in 2012, and credit and debit ...
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Infinisource's NXG series sets new time clock standard 2
(Date:1/22/2015)... January 22, 2015 GEA Niro Soavi ... top laboratory homogenizer, the PandaPLUS 2000, which is ideal ... , and cell disruption . This compact laboratory ... fruit juices, liquid food, food additives and ingredients as ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Crystal Diagnostics (CDx) ... that it has received AOAC-PTM Certifications for the six non-O157 ... and O145; collectively referred to as STEC or the “Big-6”) ... colony forming unit (cfu) per 325 g of raw ground ...
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision ... tools to enable the broad use of genomic, imaging and ... the appointment of Michelle Munson , CEO of Aspera, ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
Breaking Biology Technology:GEA Niro Soavi Announces the PandaPLUS 2000 Homogenizer for Processing New Applications for Nanoemulsions and Cell Disruption 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2GenoSpace Expands Board with Appointment of Michelle Munson 2
Cached News: