HOME >> BIOLOGY >> NEWS
CSHL scientists confirm genetic distinction between heritable and sporadic cases of autism

Autism is thought to be the most highly heritable of all neuro-psychiatric disorders. Yet, most cases of this childhood developmental disorder that severely affects social interaction and communication are "sporadic" and come with no family history. New research, led by Cold Spring Harbor Laboratory (CSHL) scientists Jonathan Sebat, Lakshmi Muthuswamy and Michael Wigler, has found a distinction between heritable and sporadic forms of the disease. These findings may influence future autism research and diagnostic testing.

"We found that many children with autism have spontaneous mutations in their DNA. This occurs more often in the sporadic cases than in either familial cases or in healthy children," said Sebat. The study, published in the March 16, 2007 edition of Science, reports that at least 10% of children with autism carry an alteration in their DNA that is not found in either parent, a much higher rate than is observed in healthy children. To date, most genetic studies of autism have focused on families with multiple autistic children. "Our findings suggest that sporadic autism is genetically distinct from the type that runs in families, and that we must use different approaches for studying them," concluded Sebat.

"Sporadic autism is the more common form of the disease, and even the inherited form might derive from a mutation that occurred in a parent or grandparent," explained Wigler. Using a high-resolution method for analyzing DNA called microarray technology, the researchers found that spontaneous copy number mutations occur primarily in sporadic cases. The study reports that these new mutations were found less frequently in families that have more than one child with autism.

The results strengthen the scientific basis for using microarray technology for diagnostic testing. Methods for detecting spontaneous mutations will provide important information for children with autism and their parents. This information could
'"/>


19-Mar-2007


Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Smithsonian scientists show differing patterns of rainforest biodiversity
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Cornell scientists link E. coli bacteria to Crohns disease
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. ASBMB taps 8 scientists and 1 politician for top awards
7. UF, French scientists seek test to detect gene doping in athletes
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. Forsyth scientists gain new understanding of adult stem cell regulation
10. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
11. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... August 03, 2020 , ... ... new partnership with medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing ... their laboratory supply chain for more than 10 years. Early in the COVID-19 ...
(Date:7/18/2020)... TORONTO (PRWEB) , ... July 17, 2020 , ... Commercial ... hangs on pharma’s ability to discover a COVID cure or vaccine, the global economic ... competitive and price pressure is not going away and capturing full value from every ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... has announced a publication detailing the use of its revolutionary NEXTGENPCR endpoint ... reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR protocol ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, the global ... has been named one of the 100 most inspiring individuals in the life-sciences ... are selected based on how they have inspired their colleagues and affected positive ...
(Date:7/31/2020)... ... July 29, 2020 , ... Diversified Technologies, Inc. has ... be configured to drive Klystrons, TWTs, IOTs, and magnetrons. , DTI Radar ... switches in a push-pull configuration; yielding fast fall time for a capacitive load. ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory Gating ... countries, has reached its 20th anniversary of worldwide use. Introduced in the US ... universities including University of Pennsylvania, University of Michigan, University of Maryland, University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... “We are thrilled to ... Bioactives. “It’s the only technology of its kind on the market and we were ... with the protective capacity of traditional cultured ingredients, creating a natural way to extend ...
Breaking Biology Technology:
Cached News: