HOME >> BIOLOGY >> NEWS
Can the tonsils influence oral HIV transmission?

Bethesda, MD Current research demonstrates that the tonsils may possess the necessary factors to act as a transmission site for the spread of HIV. The related report by Moutsopoulos et al, Tonsil Epithelial Factors May Influence Oropharyngeal Human Immunodeficiency Virus Transmission, appears in the August issue of The American Journal of Pathology.

Human immunodeficiency virus (HIV) spreads mainly through sexual contact of mucosal surfaces, which the virus must cross to come in contact with underlying immune cells for infection to occur. While the oral mucosal surfaces are largely protected by their thickened exterior and the defensive proteins present in saliva, it is speculated that a low number of infections may occur via oral sexual contact. Researchers have questioned whether such transmission is facilitated by the tonsils, which contain high numbers of immune cells that may be easily accessible to HIV.

Researchers led by Dr. Sharon M. Wahl, of the National Institute of Dental and Craniofacial Research, NIH, examined this question by comparing the gene expression profiles of tonsils and oral gingiva. Although many of the genes examined showed similar expression patterns between the two oral sites, differences were observed. Notably, several genes related to immune functions, including HIV co-receptor CXCR4, displayed significantly higher expression in the tonsils while gingiva more strongly expressed keratin genes, which thicken the tissue and provide barrier protection.

Further, Dr. Wahls group found that CXCR4 protein was expressed on gingiva, oral mucosa and tonsils, but the expression was strongest in tonsils, particularly in regions where immune surveillance is known to occur. Levels of additional molecules that may bind and entrap HIV, such as complement receptors and FcR, were also higher in the tonsils. However, when antiviral proteins were examined, lower levels of SLPI (secretory leukocyte protease inhibitor), defen
'"/>

Contact: Audra Cox
acox@asip.org
301-634-7409
American Journal of Pathology
26-Jul-2007


Page: 1 2

Related biology news :

1. Strength of connections between brain regions may affect an adolescents response to peer influence
2. UCLA researchers show that culture influences brain cells
3. Fine particulate matter from traffic may influence birth weight
4. TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
5. Childhood environment influences reproductive function
6. A relative of anti-aging gene Klotho also influences metabolic activity, obesity
7. Spousal choices can influence the risk of developing alcoholism
8. Similar brain chemicals influence aggression in fruit flies and humans
9. Location, location -- Cell sizes, lives influenced by host size
10. Folate and B12 may influence cognition in seniors
11. Evolutionary influences on proteins

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Can the tonsils influence oral HIV transmission

(Date:11/7/2014)... , Nov. 7, 2014  In conjunction with the ... Police Departments, The Community Foundation of the Verdugos has announced ... DNA JUSTICE PROJECT," a $250,000 initiative to keep the Verdugo ... In its first six months of existence, the Lab has ... support for local law enforcement. "Because our number ...
(Date:11/6/2014)... cancer deaths occur because of metastasis, yet progress ... been slow. , "It,s been particularly challenging to ... Gujral, research fellow in systems biology at Harvard ... detected until after they,ve already metastasized." , Gujral ... that should help researchers better understand how metastasis ...
(Date:11/5/2014)... Santamaria, associate professor of biology in the UTSA ... in the nation selected to receive a two-year ... for Exploratory Research (EAGER). The funding supports President ... researchers to create new technology that will demystify ... complex behaviors in neuroscience are broken into the ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
(Date:11/21/2014)... 20, 2014 Polaris Group announced today ... its Phase 1 trial of ADI-PEG 20 in ... of malignant pleural mesothelioma (MPM) and non-squamous non-small ... trials on ADI-PEG 20, both as monotherapy and ... of several other indications, including breast cancer, melanomas, ...
(Date:11/21/2014)... GUELPH, ON , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... month and nine month periods ended September 30, 2014.  Biorem,s complete ... SEDAR ( www.sedar.com ). Financial Summary:Three-months ended ... CDN$,000 except per share data) , 2014 , ... , 2,282 , 5,281 , 6,715 ...
(Date:11/18/2014)... (PRWEB) November 17, 2014 ... open architecture blade-based and rackmount computing infrastructure, today ... K80 dual-GPU accelerator throughout its GPU-enabled blade server ... of the company’s latest proprietary 80-lane Gen3 PCIe ... discrete NVIDIA Tesla K80 dual-GPU accelerator cards in ...
(Date:11/18/2014)... New Brunswick, NJ (PRWEB) November 18, 2014 ... of Data Quality and Transparency Reporting solutions, announced ... has gone live using its Consummate Provider™ solution ... Consummate Provider™ is a Global, SaaS based, Data ... Science organizations and their third party Providers improve ...
Breaking Biology Technology:Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2
Cached News: