HOME >> BIOLOGY >> NEWS
Can the tonsils influence oral HIV transmission?

Bethesda, MD Current research demonstrates that the tonsils may possess the necessary factors to act as a transmission site for the spread of HIV. The related report by Moutsopoulos et al, Tonsil Epithelial Factors May Influence Oropharyngeal Human Immunodeficiency Virus Transmission, appears in the August issue of The American Journal of Pathology.

Human immunodeficiency virus (HIV) spreads mainly through sexual contact of mucosal surfaces, which the virus must cross to come in contact with underlying immune cells for infection to occur. While the oral mucosal surfaces are largely protected by their thickened exterior and the defensive proteins present in saliva, it is speculated that a low number of infections may occur via oral sexual contact. Researchers have questioned whether such transmission is facilitated by the tonsils, which contain high numbers of immune cells that may be easily accessible to HIV.

Researchers led by Dr. Sharon M. Wahl, of the National Institute of Dental and Craniofacial Research, NIH, examined this question by comparing the gene expression profiles of tonsils and oral gingiva. Although many of the genes examined showed similar expression patterns between the two oral sites, differences were observed. Notably, several genes related to immune functions, including HIV co-receptor CXCR4, displayed significantly higher expression in the tonsils while gingiva more strongly expressed keratin genes, which thicken the tissue and provide barrier protection.

Further, Dr. Wahls group found that CXCR4 protein was expressed on gingiva, oral mucosa and tonsils, but the expression was strongest in tonsils, particularly in regions where immune surveillance is known to occur. Levels of additional molecules that may bind and entrap HIV, such as complement receptors and FcR, were also higher in the tonsils. However, when antiviral proteins were examined, lower levels of SLPI (secretory leukocyte protease inhibitor), defen
'"/>

Contact: Audra Cox
acox@asip.org
301-634-7409
American Journal of Pathology
26-Jul-2007


Page: 1 2

Related biology news :

1. Strength of connections between brain regions may affect an adolescents response to peer influence
2. UCLA researchers show that culture influences brain cells
3. Fine particulate matter from traffic may influence birth weight
4. TU Delft tracks the influence of a cancer inhibitor on a single DNA molecule
5. Childhood environment influences reproductive function
6. A relative of anti-aging gene Klotho also influences metabolic activity, obesity
7. Spousal choices can influence the risk of developing alcoholism
8. Similar brain chemicals influence aggression in fruit flies and humans
9. Location, location -- Cell sizes, lives influenced by host size
10. Folate and B12 may influence cognition in seniors
11. Evolutionary influences on proteins

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Can the tonsils influence oral HIV transmission

(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/9/2015)... SAN JOSE, Calif. , April 9, 2015 /PRNewswire/ ... of human interface solutions, announced today that it will ... 2015 on Thursday, April 23, 2015, after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3Synaptics to Report Third Quarter Results on April 23 2
(Date:4/27/2015)... , 27 avril 2015 ... spécialisée dans le développement d,une nouvelle ... les infections bactériennes polypharmacorésistantes potentiellement mortelles, ... données prouvant les promesses de son ... la lutte contre la résistance aux ...
(Date:4/27/2015)... 2015 SynGen Inc., a company that focuses ... harvest stem and progenitor cells from umbilical cord blood, ... that it has added three new members to its ... Business Units focus on product commercialization. ... Vice President and Chief Financial Officer.  Chuck was most ...
(Date:4/27/2015)... Texas (PRWEB) April 27, 2015 ... for use in applications such as animal waste ... and oil reduction in wastewater treatment plants and ... an exhibitor at the Texas Commission on Environmental ... 5-6 in Austin, Texas. , The company will ...
(Date:4/27/2015)... Diasome Pharmaceuticals, Inc. (“Diasome”) has announced ... Center (“Joslin”) to collaborate on the design of ... Directed Vesicle (“HDV”) targeting system for insulin in ... in Boston, Massachusetts, Joslin is the world's leading ... to the prevention, treatment and cure of diabetes. ...
Breaking Biology Technology:TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 2TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 3TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 4TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 5TAXIS Pharmaceuticals démontre la puissance clinique du TXA709 dans la lutte contre la résistance aux antibiotiques 6SynGen Inc. Expands Its Management Team 2DryLet to Showcase Multiple Products at Texas Commission on Environmental Quality Trade Fair and Conference May 5-6 in Austin, Texas 2Diasome Pharmaceuticals Announces Clinical Trial Design Collaboration 2
Cached News: