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Can the tonsils influence oral HIV transmission?

sins, and thrombospondin were found in the tonsils.

Altogether, Moutsopoulos et als data suggest that increased expression of molecules associated with HIV binding and entry coupled with decreased innate antiviral factors may render the tonsil a potential site for oral transmission. The decreased amount of keratin and antiviral proteins in the tonsils renders this tissue more permeable to foreign invaders, thus allowing tonsils to function in immune surveillance. However, it also renders the site more accessible to pathogens that infect immune cells. Future studies will elucidate how host vulnerability is influenced by tonsils during exposure to HIV.


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Contact: Audra Cox
acox@asip.org
301-634-7409
American Journal of Pathology
26-Jul-2007


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