HOME >> BIOLOGY >> NEWS
Cancer-reducing benefits of preventive surgery may be specific to gene mutation

ATLANTA -- A new multicenter study is the first to suggest that the prophylactic removal of the ovaries and fallopian tubes may provide a different benefit for women who carry a genetic mutation in the BRCA2 gene than for those who have a BRCA1 genetic mutation. The results of the study, which are being presented today at the annual American Society of Clinical Oncology meeting, also provide the strongest evidence to date that this surgery significantly reduces the overall risk of BRCA-associated breast and ovarian cancers.

"These findings will help doctors to better counsel women who have an inherited predisposition to ovarian and breast cancers and allow tailoring of risk-reduction strategies depending on what particular mutation a woman has inherited," said the study's lead author Noah D. Kauff, MD, a gynecologist and geneticist at Memorial Sloan-Kettering Cancer Center (MSKCC).

The study followed 886 women over the age of 30 who carry the BRCA1 or BRCA2 genetic mutation. Of this group, 561 opted to have their ovaries and fallopian tubes surgically removed -- a procedure called risk-reducing salpingo-oophorectomy -- while 325 chose to participate in ovarian surveillance. The women were followed for 40 months via questionnaire or medical review.

The results showed that overall the prophylactic surgery reduced the incidence of ovarian and related cancers by 89 percent and decreased breast cancer incidence by 47 percent. When broken down further, the results indicate that none of the women carrying the BRCA2 mutation who had the surgery developed ovarian cancer, while women carrying the BRCA1 mutation who had the surgery decreased their risk of developing ovarian or related cancers by 87 percent.

The study showed that women with BRCA2 mutations also reduced their risk of developing breast cancer by 72 percent, while those with BRCA1 mutations reduced their risk of breast cancer by 39 percent. Why the results of the procedure differ
'"/>

Contact: Maria Connizzo
mediastaff@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
5-Jun-2006


Page: 1 2

Related biology news :

1. Cardio exercise benefits in male vs. female hearts
2. Researchers probe risks, benefits of folic acid fortification
3. Research ends debate over benefits of butterfly defenses
4. Nanotechnology: consumers must be convinced benefits outweigh risks
5. Penn study finds ICD devices offer heart patients life-saving benefits
6. Wilson Center and Pew Charitable Trusts expand efforts to examine risks/benefits of nanotechnology
7. Pioneering research into health benefits of beauty treatment
8. Flavanols in cocoa may offer benefits to the brain
9. Maternal seafood consumption benefits childrens development
10. Chromium picolinate shows greater benefits in diabetes care than other forms of chromium
11. Research to spotlight carbon monoxide benefits

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... April 20, 2017  Eli Lilly and Company (NYSE: ... evaluating galcanezumab for the prevention of migraine at the ... take place April 22-28, 2017, in Boston ... abstracts at AAN, including safety and patient outcomes data ... with a reduction in monthly migraine headache days among ...
(Date:4/20/2017)... ... April 20, 2017 , ... NetDimensions appoints Bill Mastin, a learning technology ... years of experience in the learning technologies industry, Mastin joins NetDimensions from the New ... Group plc (LTG). At LEO, Mastin served as SVP of the North America offices ...
(Date:4/20/2017)... ... ... Parallel6™ , the leader in mClinical™ technologies for improving patient enrollment, ... of the 2017 Top 10 eClinical Trial Management Solution Providers by Pharma Tech ... take pride in honoring Parallel6 as one of the top 10 companies that are ...
(Date:4/20/2017)... N.J. and PETACH TIKVAH, Israel ... BCLI), a leading developer of adult stem cell technologies for ... Executive Officer, will present at the Alliance for Regenerative Medicine,s ... Day on Thursday, April 27, 2017 at 09:40 EDT in ... Ralph Kern , MD, MHSc, Chief Medical Officer & ...
Breaking Biology Technology:
Cached News: