Cancer scientists call for a large-scale human epigenome project

A vast code, invisible to the DNA sequencing effort that constituted the Human Genome Project, is rapidly being shown to play a direct role in human health. This "epigenome" - from the Greek epi, meaning "in addition to" - consists of chemical "amendments" that dangle like charms on a bracelet from the linear string of letters that spell out the genetic code.

Now, an international group of 40 leading cancer scientists says the time is ripe to undertake a large-scale international "Human Epigenome Project" designed to map the chemical modifications to DNA that comprise the epigenetic code. Their proposal, "A Blueprint for a Human Epigenome Project" -- published in the December 15, 2005 issue of Cancer Research -- summarizes the findings of an AACR-sponsored workshop held June 15-18, 2005, in Lansdowne, Va.

"Definition of the human epigenome and its application to developing diagnostic, prognostic and therapeutic tools will likely produce some of the earliest translational research benefits flowing from large-scale genome initiatives to the bedside," said Frank Rauscher, III, Ph.D., editor-in-chief of Cancer Research.

"It is time to create a concerted international effort to unlock the epigenomic information stored in our genome and use it for the benefit of human health," he added.

The new report spells out the needs, guidelines and expectations of a Human Epigenome Project (HEP), and describes the developing technologies that make the project currently feasible.

"One of the most exciting points to emerge from the meeting is that the technology needed for doing epigenetics on a high-throughput basis has advanced so far that people are already engaged in epigenomic studies on a piecemeal basis," said Peter A. Jones, Ph.D., D. Sc., president of the American Association for Cancer Research (AACR) and Director of the Norris Comprehensive Cancer Center at the University of Southern California. Jones and Robert Martienssen

Contact: Warren R. Froelich
American Association for Cancer Research

Page: 1 2 3 4

Related biology news :

1. Journalists can register now for ECCO 14 -- the European Cancer Conference
2. Cancer cures could work for canines and humans
3. The Cancer Genome Atlas awards funds for technology development
4. Cancer research specialist and HSPH professor awarded Medal of Honor from WHO cancer agency
5. Cancer stem cells similar to normal stem cells can thwart anti-cancer agents
6. Cancer stem cells can go it alone
7. Cancer drug enhances long-term memory
8. Cancer cells reprogram energy needs to grow and spread, study suggests
9. Cancer scientists create human leukemia process to map how disease begins, progresses
10. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
11. Other highlights from the April 18 Journal of the National Cancer Institute

Post Your Comments:

(Date:8/3/2020)... , ... August 03, 2020 , ... ... announced a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 ... to strengthen their laboratory supply chain for more than 10 years. Early in ...
(Date:7/18/2020)... ... July 16, 2020 , ... A ... of the Invictus Medical Neoasis™ active noise control device to attenuate typical noises ... the Neoasis™ device attenuated the alarm sounds from patient monitors, ventilators and other ...
(Date:7/4/2020)... ... July 03, 2020 , ... ... earn outstanding recognition and multiple awards for not only the products and treatments ... SoME® Skincare and Vivace® Microneedle RF. All the brands built by ABM have ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
(Date:7/31/2020)... ... July 30, 2020 , ... Alucio™, ... announced the release of its signature product called Beacon - a content ... other field medical professionals. , Beacon helps MSLs streamline communication and ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a ... and food industries, is pleased to announce that Charles Galea has joined its ... , Charles is an accomplished and results-driven sales executive with over 10 years ...
(Date:7/7/2020)... ... 2020 , ... R3 International is now offering stem cell therapy for Alzheimers ... Depending on the patient's condition, treatment may be offered IV, intrathecal or with a ... of Alzheimers dementia, and the incidence continues to increase as individuals live longer. There ...
Breaking Biology Technology:
Cached News: