HOME >> BIOLOGY >> NEWS
Cancer therapies during childhood can damage developing teeth

Research published by the University of Helsinki, Finland, indicates that cytostatic and radiation therapies administered before stem cell transplantation often damage children's permanent teeth.

Detrimental effects of cytostatic and radiation therapies on dental development have been known for a long time, but knowledge about the dental consequences of high-dose anticancer therapy preceding stem cell transplantation has so far been scarce. Pivi Hltt, Licentiate in Dentistry, from the Institute of Dentistry, University of Helsinki, has studied the effects of high-dose anticancer chemotherapy and total body irradiation on the development of permanent teeth.

Tooth development is a genetically controlled chain of events that can be disturbed by various environmental factors. The development of permanent teeth begins as early as the 20th week of gestation and continues until the age of 14 to 15 years with the exception of wisdom teeth, which still continue their development for several years. All this time teeth are vulnerable to developmental aberrations.

The children examined in the current study, treated for cancer or aplastic anemia, had received stem cell transplantation at the age from 1 to 9.4 years, preceded with a high-dose anticancer chemotherapy and, in most cases, with total body irradiation. In her research, Hltt studied how many of the treated children lacked permanent teeth or had unusually small teeth, and how often dental roots were poorly developed.

The results indicated that 31% of the treated children lacked permanent teeth (as opposed to 8% of the Finnish population), when wisdom teeth were excluded. Lack of permanent teeth was most frequent (77%) among children who had been less than three years old at stem cell transplantation. The highest number of missing teeth was 12. Those who had been over five years of age at stem cell transplantation lacked only wisdom teeth. A significant finding was that a high-dose antica
'"/>

Contact: Pivi Hltt
paivi.holtta@helsinki.fi
358-40-560-9711
University of Helsinki
29-Aug-2005


Page: 1 2

Related biology news :

1. Journalists can register now for ECCO 14 -- the European Cancer Conference
2. Cancer cures could work for canines and humans
3. The Cancer Genome Atlas awards funds for technology development
4. Cancer research specialist and HSPH professor awarded Medal of Honor from WHO cancer agency
5. Cancer stem cells similar to normal stem cells can thwart anti-cancer agents
6. Cancer stem cells can go it alone
7. Cancer drug enhances long-term memory
8. Cancer cells reprogram energy needs to grow and spread, study suggests
9. Cancer scientists create human leukemia process to map how disease begins, progresses
10. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
11. Other highlights from the April 18 Journal of the National Cancer Institute

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... Switzerland (PRWEB) , ... June ... ... provider of enterprise software solutions for biopharmaceutical R&D, today announced that it ... company developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational and ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around for ... use of mass spectrometry in this field has gained a lot of momentum in ... which approach to use (LBA or MS)?” In many cases, either technology can ...
(Date:6/19/2020)... ... , ... Join experts from Envigo Lauren Klaskala, Project Manager – ... on Wednesday, July 8, 2020 at 11am EDT (4pm BST/UK). , Nuclease-based technologies ... However, while modifying the genome may be more straightforward, the challenge to create an ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the ... new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at a ... fast track capacity to provide patients with urgently needed vaccines and other lifesaving ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, Inc. ... of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell and ... a strategic partnership whereby Catalent will provide support for the development, manufacturing, and ...
(Date:7/31/2020)... ... July 30, 2020 , ... Alucio™, ... announced the release of its signature product called Beacon - a content ... other field medical professionals. , Beacon helps MSLs streamline communication and ...
(Date:7/18/2020)... MILWAUKEE (PRWEB) , ... July 16, 2020 , ... “We ... at Third Wave Bioactives. “It’s the only technology of its kind on the market ... flavor of onions with the protective capacity of traditional cultured ingredients, creating a natural ...
Breaking Biology Technology:
Cached News: