HOME >> BIOLOGY >> NEWS
Carbon monoxide: Poison gas or anti-inflammatory drug?

Could become part of future treatment regimen for organ transplant patients.

ANN ARBOR, Mich. Carbon monoxide, a poisonous gas that kills thousands of Americans every year, could turn out to be a life-saver for patients recovering from organ transplants, strokes or heart attacks, according to new research from the University of Michigan Cardiovascular Center.

In a recent study, U-M scientists found that inhaling small amounts of carbon monoxide for several weeks after transplant surgery prevented the development of a lethal inflammatory reaction in experimental mice receiving transplanted trachea, or windpipes.

If carbon monoxide therapy works as well in human patients as it does in mice, it could prevent an inflammatory response, called obliterative bronchiolitis, which develops in nearly 50 percent of all patients who receive a lung transplant from an unrelated donor. OB is the most common complication following a lung transplant in humans and the most deadly. It occurs when the patient's immune system rejects the transplanted lung and sends an army of T cells to attack and destroy the foreign tissue.

"No one is sure exactly how it happens, but the small airways in the lung swell and become progressively smaller until the patient cannot breathe," says David J. Pinsky, M.D., the J. Griswold Ruth, M.D. & Margery Hopkins Ruth Professor of Internal Medicine and chief of cardiovascular medicine in the U-M Medical School, who directed the research. "Currently, we have no effective treatments for OB. Unless the patient receives a new lung transplant, the outcome is generally fatal."

Results of the U-M study were published July 18 in the most recent issue of the Journal of Experimental Medicine (JEM).

Pinsky's research team focuses on the relationship between carbon monoxide and nitric oxide two poisonous gases produced by different types of cells in the body. U-M research findings suggest that a patient's c
'"/>


28-Jul-2005


Page: 1 2 3 4

Related biology news :

1. Tough tubes -- Carbon nanotubes endure heavy wear and tear
2. Carbon dioxide and the ocean
3. Carbon monoxide protects mice from multiple sclerosis
4. Carbon monoxide protects lung cells against oxygen-induced damage
5. On the cutting edge: Carbon nanotube cutlery
6. Carbon capture, water filtration, other boreal forest ecoservices worth estimated $250 billion/year
7. Carbon monoxide may help prevent debilitating pregnancy condition
8. Carbon cycle was already disrupted millions of years ago
9. Carbon monoxide inhibitor controls traumatic bleeding, Tulane University researchers show
10. Carbon nanotube absorption measured in worms, cancer cells
11. Carbon nanotubes that detect disease-causing mutations developed by Pitt researcher

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... August 06, 2020 , ... ... in the prestigious National STEM Scholar Program, a unique professional development program that ... project support for middle school science teachers nationwide. , Created in partnership between ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... therapeutics product portfolio with a near term focus on Type 2 diabetes and ... commercialization experience across multiple therapeutic areas and classes. As Chief Commercial Officer, Justin ...
(Date:7/10/2020)... ... 08, 2020 , ... Overcoming Comparability Issues in Regenerative Medicines ... Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy , ... way to complete one? Will the study comply with all FDA requirements? Understanding ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... ... Jim Corrigan, President and CEO has been named one of the 100 most ... industry sectors, PharmaVoice 100 honorees are selected based on how they have inspired ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... that can combine up to three different materials for use with CRM, neurostimulation, ... up to three materials to meet specific design requirements, performance, and cost criteria; ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). ... Specifically, for medical devices, the NMPA has departments dealing with medical device registration (pre-market ...
(Date:7/10/2020)... (PRWEB) , ... July 08, 2020 , ... ... services and products, announces a significant expansion of laboratory operations through its ... for agencies implementing testing programs. , Bode-CARES provides a turnkey ...
Breaking Biology Technology:
Cached News: