Carbon monoxide inhibitor controls traumatic bleeding, Tulane University resear...( lated as expected because the endothel...)

lated as expected, because the endothelium produces the dilator NOS. But vessels with damaged endothelium, in which NOS was inhibited, constricted. This showed that blocking carbon monoxide narrows the blood vessel opening under conditions of massive soft tissue trauma, and limits bleeding.

In the second phase, the researchers anesthetized two groups of rats, lacerated the livers and measured the drop in blood pressure over two hours. The blood pressure of the rats that received the CO blocker remained higher for a longer time and significantly prolonged survival.

"It's exciting because it can have so many implications," McCarty said of the research. Not only could it be used to save wound victims and reduce the need for transfusions for surgery patients, but the principal could be applied as a precaution to soldiers in battle zones. In fact, it may be possible to provide a diet that contains the preventative treatment.

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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
6-Apr-2006

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