HOME >> BIOLOGY >> NEWS
Carbon monoxide protects lung cells against oxygen-induced damage

PITTSBURGH, Jan. 18 -- Researchers at the University of Pittsburgh have demonstrated that low-dose carbon monoxide administered in conjunction with oxygen therapy markedly inhibits oxygen-induced damage to lung cells. These findings, being reported in the Jan. 19 issue of the Journal of Biological Chemistry, have significant implications for the treatment of acute respiratory distress syndrome, or ARDS, according to the study's authors.

ARDS is a life-threatening medical condition in which patients experience severe shortness of breath and oxygen starvation. Although ARDS often occurs in people who have lung disease, even people with normal lungs can develop the condition as the result of severe trauma or an infection. Without prompt treatment, the oxygen deprivation resulting from ARDS can be lethal. Even with appropriate treatment, however, about 30 to 40 percent of all people with severe ARDS die from the condition. In fact, it is the number one killer of patients in intensive care unit facilities in the United States.

Treatment for ARDS primarily involves hooking the patient up to a mechanical ventilator and giving them almost pure oxygen (95 percent oxygen and 5 percent carbon dioxide). However, recent studies in animals have shown that prolonged exposure to an elevated level of oxygen, or hyperoxia, can cause long-term lung injury that resembles ARDS.

Based on previous research showing that low-dose carbon monoxide (CO) has potent anti-inflammatory effects in a number of tissues, the Pitt researchers cultured lung cells from mice in a medium with a high concentration of oxygen, with and without low levels of CO. They then monitored the cells for hyperoxia-induced toxicity.

The presence of CO in the hyperoxic medium significantly inhibited the destruction of lung cells as well as the production of molecules in the cells that are known to induce cell suicide, or apoptosis. In contrast, more than half of the mouse lung
'"/>

Contact: Jim Swyers
SwyersJP@upmc.edu
412-647-3555
University of Pittsburgh Medical Center
18-Jan-2007


Page: 1 2

Related biology news :

1. Tough tubes -- Carbon nanotubes endure heavy wear and tear
2. Carbon dioxide and the ocean
3. Carbon monoxide protects mice from multiple sclerosis
4. On the cutting edge: Carbon nanotube cutlery
5. Carbon capture, water filtration, other boreal forest ecoservices worth estimated $250 billion/year
6. Carbon monoxide may help prevent debilitating pregnancy condition
7. Carbon cycle was already disrupted millions of years ago
8. Carbon monoxide inhibitor controls traumatic bleeding, Tulane University researchers show
9. Carbon nanotube absorption measured in worms, cancer cells
10. Carbon nanotubes that detect disease-causing mutations developed by Pitt researcher
11. Carbon nanoparticles stimulate blood clotting, researchers report

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/9/2020)... ... April 08, 2020 , ... ... learning, performance, and process solutions for the life sciences industry, has invested ... offering process-enabled technology solutions for the global pharmaceutical industry. Pyxa’s flagship software ...
(Date:4/1/2020)... ... March 30, 2020 , ... eMazzanti Technologies, ... said today that the previously announced Align2020 conference will be conducted virtually. ... and C-level executives as they face current cyber security, compliance and collaboration challenges. ...
(Date:3/20/2020)... ... 20, 2020 , ... OUHSC and Pure MHC have launched a research collaboration ... team is led by William Hildebrand, Ph.D., whose expertise is helping the body’s protective ... part of a family of biotechnology companies formed, funded and managed by Austin, TX ...
Breaking Biology News(10 mins):
(Date:2/11/2020)... ... February 11, 2020 , ... ... announce the successful results from a long-term follow-up clinical study of outpatient ... fixation device (INSPAN LLC). Unlike extension block design, the Inspan device fixates ...
(Date:2/10/2020)... ... 2020 , ... R3 Medical Training announced it is now registering for its ... The course is hands on involving real patients and stem cell biologics, with every ... Stem Cell Training Course has received rave reviews from attendees, who love the hands ...
(Date:2/5/2020)... Fla. (PRWEB) , ... February 05, 2020 , ... ... annual observance, sponsored by The National Organization for Rare Disorders (NORD), to raise awareness ... lives ( rarediseaseday.org ). The Balancing Act’s “Behind The Mystery” rare disease ...
(Date:2/3/2020)... ... February 03, 2020 , ... ... Cambridge, MA, announce that OmniType, the 11-locus, single tube multiplex successor to Holotype ... a best-in-class product featuring locus-multiplexing and short library preparation, for HLA genotyping from ...
Breaking Biology Technology:
Cached News: