HOME >> BIOLOGY >> NEWS
Cardiac patches stimulate regeneration, improve function after heart attack

When human hearts are injured, as during a heart attack, healthy tissue normally cant regrow. Researchers now demonstrate in rats that a sponge-like patch, soaked in a compound called periostin and placed over the injury, can not only get heart cells to begin dividing and making copies of themselves again, but also improves heart function. Their findings appear in the July 15 online edition of Nature Medicine.

Periostin is a component of the material that surrounds cells and is derived from the skin around bone. Though the mature heart only has tiny amounts, its abundant during fetal heart development, and increased amounts are also made after skeletal-muscle injury, bone fracture and blood vessel injury, stimulating mature, specialized cells to begin dividing again. Led by Bernhard Kuhn, MD, in the Department of Cardiology at Childrens Hospital Boston, the researchers theorized that placing periostin near the site of a myocardial infarction could help restore this growth-friendly environment and get heart tissue to regenerate.

Kuhn and colleagues at Massachusetts General Hospital and the Mount Sinai School of Medicine first stimulated mature, rod-shaped heart muscle cells (known as cardiomyocytes) with periostin in a Petri dish. About 1 percent of the cells entered the mitotic cell cycle namely, they began dividing and replicating. (One percent seems like a small proportion, but normally the percentage is close to zero.)

We found a small subpopulation of cells that could, with proper stimulation, re-enter the cell cycle, says Kuhn, who was awarded the Young Investigators Award for this research by the American College of Cardiology in March. This finding supports the idea that differentiated cardiomyocytes can proliferate.

Using a small patch fashioned from a sponge-like material called Gelfoam, they then moved to experiments in rats with induced heart attacks. In half the rats, a patch that had been incubated with peri
'"/>

Contact: Anna Gonski
anna.gonski@childrens.harvard.edu
617-355-6420
Children's Hospital Boston
17-Jul-2007


Page: 1 2

Related biology news :

1. Antidepressants stimulate new nerve cells in adult monkeys, may have implications for humans
2. Oxidative stress stimulates p38 MAPK-mediated tumor suppression
3. Best of both worlds -- Targeting a single gene could inhibit bone decay and stimulate bone growth
4. New vaccine stimulates colorectal cancer patients immune systems to fight cancerous cells
5. Harvard scientists identify compounds that stimulate stem cell growth in the brain
6. Sexual competition stimulates premature and repeated ejaculation in a mammal
7. Novel vaccine approach stimulates protective immunity against listeria
8. New study shows antibody-interleukin complexes stimulate immune responses
9. Carbon nanoparticles stimulate blood clotting, researchers report
10. New battery technology helps stimulate nerves
11. Component of plastic stimulates growth of certain prostate cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/31/2017)... , Jan. 31, 2017  Spero Therapeutics, LLC, ... for the treatment of bacterial infections, today announced ... antibacterial candidates from Pro Bono Bio Ltd (PBB) ... of multi-drug resistant forms of Gram-negative bacteria.   The ... Infectives Ltd, a PBB group company. ...
(Date:1/25/2017)... Jan. 25, 2017 The Elements of Enterprise ... lifecycle is comprised of a comprehensive set of ... of maintaining digital identities and providing a secured ... There are significant number of programs opted by ... time by optimizing processes and changing policies. However, ...
(Date:1/21/2017)... Research and Markets has announced the addition of the ... ... voice recognition biometrics market to grow at a CAGR of 19.36% ... present scenario and the growth prospects of the global voice recognition ... considers the revenue generated from the sales of voice recognition biometrics ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... , ... February 27, 2017 , ... The Catalyst ... a few in the Midwest offering premix services and private label organic services. , ... laying hens, according Jos Zamzow, chief operating officer of Dynamite Marketing, which owns the ...
(Date:2/24/2017)... ... February 24, 2017 , ... ... be safely completed in an ambulatory surgery center (ASC) with satisfactory clinical and ... previous two-year TDR studies. , Jake Lubinski, president of AxioMed, commented on ...
(Date:2/24/2017)... Tenn. , Feb. 24, 2017 ... ("Provectus" or the "Company"), a clinical-stage oncology and ... regarding the deadline to participate in its previously ... units, consisting of shares of common stock and ... and holders of listed warrants. ...
(Date:2/24/2017)... 24, 2017  Driven by consumers, preference towards ... the fastest growing categories, finds the recently published ... Personal Care: Multi-regional Market Analysis and Opportunities ... firm Kline. "Biotechnology actives are derived ... more effective for skin and hair care applications," ...
Breaking Biology Technology:
Cached News: